Summary
The frequency of α+-thalassmia has been determined in African populations carrying βs-chromosomes of different origins. All these α+ thalassemias result from a right-ward deletion. Restriction mapping of the α-3·7/haplotype with the enzyme ApI only showed the presence of a type I crossover. RsaI polymorphism at the 5′ end of Zα2 is largely represented in the normal population (gene frequency 23%) but, in our series, never associated with the α-3·7/haplotype.
This is a preview of subscription content, log in via an institution to check access.
References
Di Rienzo A, Felicetti L, Novelleto A, Forteleoni G, Colombo B (1985) Frequency and types of deletional α+ thalassemia in Northern Sardinia. Hum Genet 71:147–149
Embury SH (1986) The clinical pathophysiology of sickle cell disease. Annu Rev Med 37:361–376
Embury SH, Clark MR, Monroy G, Mohandas N (1984) Concurrent sickle cell anemia and α-thalassemia. J Clin Invest 73:116–123
Goossens M, Dozy AM, Embury SH, Zachariades Z, Hadjiminas MG, Stamatoyannopoulos G, Kan YW (1980) Triplicated α-globin loci in humans. Proc Natl Acad Sci USA 77:518–521
Henni T, Morle F, Lopez B, Colonna P, Godet J (1987) α-Thalassemia haplotypes in the Algerian population. Hum Genet 75:272–276
Higgs DR, Hill AVS, Bowden DK, Weatherall DJ, Clegg JB (1984) Independent recombination events between the duplicated human α globin genes; implications for their concerted evolution. Nucleic Acids Res 12:6965–6977
Higgs DR, Wainscoat JS, Flint J, Hill AVS, Thein SL, Nicholls RD, Teal H, Ayyub H, Peto TEA, Falusi AG, Jarman AP, Clegg JB, Weatherall DJ (1986) Analysis of the human α-blobin geen cluster reveals a highly informative genetic locus. Proc Natl Acad Sci USA 83:5165–5169
Mears JG, Schoenbrun M, Schaeffer KE, Bestak M, Redel E (1982) Frequent association of α thalassemia with splenic sequenstration crises and splenomegaly in sickle cell (SS) subjects. Blood 60:47a
Mears JG, Lachman HM, Labie D, Nagel RL (1983) Alpha-thalassemia is related to prolonged survival in sickle cell anemia. Blood 62:286–290
Michelson AM, Orkin SH (1983) Boundaries of gene conversion within the duplicated human α globin genes. J Biol Chem 258:15245–15254
Ojwang PJ, Ogada T, Beris P, Hattori Y, Lanclos KD, Kutlar A, Kutlar F, Huisman THJ (1987) Haplotypes and α globin gene analyses in sickle cell anemia patients from Keyna. Br J Haematol 65:211–215
Pagnier J, Mears JG, Dunda-Belkhodja O, Schaefer-Rego KE, Beldjord C, Nagel RL, Labie D (1984a) Evidence for the multicentric origin of the sickle-cell hemoglobin gene in Africa. Proc Natl Acad Sci USA 81:1771–1773
Pagnier J, Dunda-Belkhodja O, Zohoun I, Teyssier J, Baya H, Jaeger G, Nagel RL, Labie D (1984b) α-Thalassemia among sickle cell anemia patients in various African populations. Hum Genet 68:318–319
Schneider RG (1974) Identification of hemoglobins by electrophoresis. In: Schmidt RM, Huisman THJ, Lehmann H (eds) The detection of hemoglobinopathies. RC Press, Cleveland
Southern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503–517
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dodé, C., Berth, A., Rochette, J. et al. Analysis of crossover type in the α-3·7 haplotype among sickle cell anemia patients from various parts of Africa. Hum Genet 78, 193–195 (1988). https://doi.org/10.1007/BF00278197
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00278197