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Three-point linkage analysis employing C3 and 19cen markers assigns the myotonic dystrophy gene to 19q

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Summary

In seven large families with myotonic dystrophy (DM) comprising 102 individuals, linkage studies were perfermed employing restriction fragment length polymorphisms in the complement component 3 gene and the 19cen C banding heteromorphism as genetic markers. Three-point linkage analysis excludes DM from the 19cen-C3 segment and strongly supports its assignment to the proximal long arm of chromosome 19.

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Authors and Affiliations

  1. Institute for Human Genetics, University of Aarhus, Aarhus, Denmark

    Ursula Friedrich

  2. Department of Human Genetics, Anthropogenetic Institute, Catholic University of Nijmegen, Geert Grooteplein Zuid 20, NL-6525 GA, Nijmegen, The Netherlands

    Han Brunner, Dominique Smeets, Eric Lambermon & Hans-Hilger Ropers

Authors
  1. Ursula Friedrich
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  2. Han Brunner
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  3. Dominique Smeets
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  4. Eric Lambermon
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  5. Hans-Hilger Ropers
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Friedrich, U., Brunner, H., Smeets, D. et al. Three-point linkage analysis employing C3 and 19cen markers assigns the myotonic dystrophy gene to 19q. Hum Genet 75, 291–293 (1987). https://doi.org/10.1007/BF00281077

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  • DOI: https://doi.org/10.1007/BF00281077

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