Summary
In a review of information on 444 patients with sporadic retinoblastoma, a correlation with increased fathers'age was demonstrated and no correlation with was found in the unilateral form. These data favor the hypothesis that the bilateral form is caused by a germinal mutation and the unilateral form is due to somatic mutations.
Zusammenfassung
In einer Übersicht über 444 Patienten mit sporadischem Retinoblastom wurde eine Erhöhung des väterlichen Alters demonstriert. Bei den einseitigen Fällen wurde eine solche Erhöhung jedoch nicht gefunden. Die Daten sprechen dafür, daß die doppelseitige Form durch Keimzell-Mutation verursacht ist, während die einseitige form auf somatische Mutationen zurückgeht.
This is a preview of subscription content, log in via an institution to check access.
References
Blank, C. E.: Aperts'syndrome (a type of acrocephalosyndactyly). Ann. hum. Genet. 24, 151–164 (1960)
Bouvet, J. P., Maroteaux, P., Feingold, J.: Etude génétique de l'achondroplasie. Ann. Génét. 14, 127–131 (1971)
Cavalli-Sforza, L. L., Bodmer, W. F.: The genetics of human population. San Francisco: Freeman & Co. 1971
Fall, H. F., Neel, J. V.: Genetics of retinoblastoma. Arch. Ophthal. 46, 367–389 (1951)
Fraser, G. R., Friedman, A. I.: The causes of blindness in childhood. Baltimore: Johns Hopkins Press 1967
Knudson, A. G.: Mutation and cancer: statistical study of retinoblastoma. Proc. nat. Acad. Sci. (Wash.) 68, 820–823 (1971)
Lynas, H. A.: Marfan's syndrome in Northern Ireland. Ann. hum. Genet. 22, 289–309 (1958)
Macklin, M. T.: A study of retinoblastoma in Ohio. Amer. J. hum. Genet. 12, 1–43 (1960)
Macklin, M. T.: A study of retinoblastoma in Ohio. Amer. J. hum. Genet. 12, 1–43 (1960)
Matsunaga, E.: Parental age and sporadic retinoblastoma. Ann. Report 16, 121 (1965)
Mørch, E. T.: Chondrodystrophic dwarfs in Denmark, Opera ex Domo Biol. Hered. Hum. Uni. Hafn. 3. Kopenhagen: Munksgaard 1941
Murdoch, J. L., Walker, B. A., Hall, J. G., Abbey, H., Smith, K. K., Mckusick, V. A.: Achondroplasia. A genetic and statistical survey. Ann. hum. Genet. 33, 227–244 (1970)
Murdoch, J. L., Walker, B. A., McKusick, V. A.: Parental age effects on the occurrence of new mutations for the marfan's syndrome. Ann. hum. Genet. 35, 331–336 (1972)
Penrose, L. S.: Parental age and mutation. Lancet 1955 II, 312–313
Penrose, L. S.: Parental age in achondroplasia and mongolism. Amer. J. hum. Genet. 9, 167–169 (1967)
Tünte, W., Becker, P. E., Von Knorre, G. V.: Zur Genetik der Myositis ossificans progressiva. Humangenetik 4, 320–351 (1967)
Tünte, W.: Human mutations and paternal age. Humangenetik 16, 77–82 (1972)
Vogel, F.: Neue Untersuchungen zur Genetik des Retinoblastoms. Z. menschl. Vererb.- u. Konstit.-Lehre 34, 205–236 (1957)
Vogel, F.: Genetic prognosis in retinoblastoma. Modern trends in ophthalmology, A. Soursky, Ed. pp. 34–42. London: Butterworths 1967
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pellié, C., Briard, ML., Feingold, J. et al. Parental age in retinoblastoma. Hum Genet 20, 59–62 (1973). https://doi.org/10.1007/BF00280877
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00280877