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Nalidixic acid does not inhibit bacterial transformation

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Summary

Nalidixic acid at concentrations that block completely the DNA replication of Bacillus subtilis does not inhibit its genetic transformation and does not appreciably affect the growth of the DNA phage SPP1 on the same organism.

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References

  • Bodmer, B.: Recombination and integration in Bacillus subtilis: involvement of DNA synthesis. J. molec. Biol. 14, 534 (1965).

    Google Scholar 

  • Cook, T. M., Brown, K. G., Boyle, J. V., Goss, W. A.: Bactericidal action of nalidixic acid on Bacillus subtilis. J. Bact. 92, 1510 (1966).

    Google Scholar 

  • Davis, P. D., Mingioli, E. S.: Mutants of Escherichia coli requiring methionine or vitamin B12. J. Bact. 60, 17 (1950).

    Google Scholar 

  • Deitz, W. H., Cook, T. M., Goss, W. A.: Mechanism of action of nalidixic acid on Escherichia coli. III. Conditions required for lethality. J. Bact. 91, 768 (1966).

    Google Scholar 

  • Gage, L. P., Fujita, D. J.: Effect of nalidixic acid on deoxyribonucleic acid synthesis in bacteriophage SPO 1-infected Bacillus subtilis. J. Bact. 98, 96 (1969).

    Google Scholar 

  • McCarthy, C., Nester, E. W.: Macromolecular synthesis in newly transformed cells of Bacillus subtilis. J. Bact. 94, 131 (1967).

    Google Scholar 

  • Polsinelli, M., Beretta, M.: Genetic recombination in crosses between Streptomyces aureofaciens and Streptomyces rimosus. J. Bact. 91, 63 (1966).

    Google Scholar 

  • Riva, S., Polsinelli, M., Falaschi, A.: A new phage of Bacillus subtilis with infectious DNA having separable strands. J. molec. Biol. 35, 356 (1968).

    Google Scholar 

  • Taketo, A., Watanabe, H.: Effect of nalidixic acid on the growth of bacterial viruses. J. Biochem. 61, 520 (1967).

    Google Scholar 

  • Young, F. E., Spizizen, J.: Physiological and genetic factors affecting transformation of Bacillus subtilis. J. Bact. 81, 823 (1961).

    Google Scholar 

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Authors and Affiliations

  1. Laboratorio di Genetica Biochimica ed Evoluzionistica del Consiglio Nazionale delle Ricerche, Pavia

    Antonia M. Pedrini, Diego Geroldi & Arturo Falaschi

  2. Istituto di Genetica, Università di Pavia, 27100, Pavia, Italy

    Diego Geroldi

Authors
  1. Antonia M. Pedrini
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  2. Diego Geroldi
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  3. Arturo Falaschi
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Communicated by G. Magni

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Pedrini, A.M., Geroldi, D. & Falaschi, A. Nalidixic acid does not inhibit bacterial transformation. Molec. gen. Genet. 116, 91–94 (1972). https://doi.org/10.1007/BF00334264

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  • DOI: https://doi.org/10.1007/BF00334264

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