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Inhibition of mitochondrial protein synthesis in vivo by erythromycin in Schizosaccharomyces pombe and Saccharomyces cerevisiae

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Summary

In the presence of erythromycin (0.01 mg/ml) growth of Schizosaccharomyces pombe in non-fermentable substrate (glycerol) is reduced to 5–15% of the control without erythromycin, whereas growth in fermentable substrate (5% glucose) is left unaffected by concentrations up to 5 mg/ml. The reduction of growth under derepressed conditions is paralleled by inhibition of the formation of cytochromes a·a3 and b. Mitochondrial protein synthesis is inhibited to about 50% in Schizosaccharomyces pombe and to about 90% in Saccharomyces cerevisiae. These results support the hypothesis that inhibition of mitochondrial protein synthesis is the primary effect of erythromycin.

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Communicated by W. Gajewski

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Michel, R., Schweyen, R.J. & Kaudewitz, F. Inhibition of mitochondrial protein synthesis in vivo by erythromycin in Schizosaccharomyces pombe and Saccharomyces cerevisiae . Molec. Gen. Genet. 111, 235–241 (1971). https://doi.org/10.1007/BF00433108

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  • DOI: https://doi.org/10.1007/BF00433108

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