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Trypanosoma cruzi : IgG1 and IgG2b are the main immunoglobulins produced by vaccinated mice

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Abstract

Mice vaccinated with CL-14, a non-infective and non-pathogenic clone isolated from Trypanosoma cruzi CL strain, become protected against lethal challenge by infective trypomastigotes. It has been shown that animals infected with T. cruzi show polyclonal activation of B lymphocytes with an early production of several non-specific immunoglobulins. Vaccinated mice, however, have an early production of antigen-specific IgG1 and IgG2b. Considering the lack of infectivity of CL-14, our data strongly suggest a role for IgG1 and IgG2b in protection to T. cruzi.

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Authors and Affiliations

  1. Instituto de Biofísica Carlos Chagas Filho, CCS, UFRJ, Ilha do Fundão, 21949-900, Rio de Janeiro, Brazil fax: +5521 280-8193, e-mail: cerli@chagas.biof.ufrj.br, , , , , , BR

    Alexandre S. Pyrrho, Jorge L. C. Moraes & Cerli R. Gattass

  2. Instituto de Microbiologia Paulo de Goes, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Ilha do Fundão, 21949-900, Rio de Janeiro, Brazil, , , , , , BR

    Lígia M. T. Peçanha

Authors
  1. Alexandre S. Pyrrho
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  2. Jorge L. C. Moraes
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  3. Lígia M. T. Peçanha
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  4. Cerli R. Gattass
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Received: 6 July 1997 / Accepted: 24 September 1997

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Pyrrho, A., Moraes, J., Peçanha, L. et al. Trypanosoma cruzi : IgG1 and IgG2b are the main immunoglobulins produced by vaccinated mice. Parasitol Res 84, 333–337 (1998). https://doi.org/10.1007/s004360050406

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  • DOI: https://doi.org/10.1007/s004360050406

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