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Localization of the mGlu4a metabotropic glutamate receptor in rat cerebellar cortex

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Abstract

 The subcellular localization of the mGlu4a metabotropic glutamate receptor was investigated in rat cerebellum. At the light microscopical level, strong mGlu4a immunoreactivity was found in the molecular layer. A post-embedding immunogold method for electron microscopy revealed gold particles at the presynaptic sites of synapses made by parallel fiber terminals with dendritic spines of Purkinje cells. These observations support electrophysiological evidence indicating an autoreceptor function of mGlu4 receptors at these synapses.

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Authors and Affiliations

  1. Department of Neurosciences, Faculty of Medicine and Dentistry, Basque Country University, E-699-48080 Bilbao, Spain Tel. +344-464 77 00 ext. 2729; fax +344-464 92 66 E-mail onpgrmop@lg.ehu.es, , , , , , ES

    J. M. Mateos, J. Azkue, R. Sarría & P. Grandes

  2. IRCCS Santa Lucia, Via Ardeatina 306, I-00179 Rome, Italy, , , , , , IT

    T. Knöpfel

  3. Department of Molecular and Cellular Biology, CNS Research, Novartis, CH-4002 Basel, Switzerland, , , , , , CH

    R. Kuhn

Authors
  1. J. M. Mateos
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  2. J. Azkue
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  3. R. Sarría
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  4. R. Kuhn
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  5. P. Grandes
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  6. T. Knöpfel
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Accepted: 1 July 1997

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Mateos, J., Azkue, J., Sarría, R. et al. Localization of the mGlu4a metabotropic glutamate receptor in rat cerebellar cortex. Histochemistry 109, 135–139 (1998). https://doi.org/10.1007/s004180050211

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  • DOI: https://doi.org/10.1007/s004180050211

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