Summary
The RBE of Cf-252 neutron irradiation was determined for hemopoietic tissue using spleen CFU-S. Radiosensitivity was compared to acute Cobalt-60 radiation and low dose rate Cesium-137 under identical irradiation conditions. The RBE for the neutron component of the Cf-252 radiation was 2.1. No dose rate effect was observed for hemopoietic CFU-S to acute doses or low dose rate photon irradiation.
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Ainsworth EJ, Jordan DL, Miller M, Cooke EM, Hulesch JS (1976) Dose rate studies with fission spectrum neutrons. Radiat Res 67: 30–45
Broerse JJ, Barendsen GW, Kersen GR (1968) Survival of cultured human cells after irradiation with fast neutrons of different energies in hypoxic and oxygenated conditions. Int J Radiat Biol 13: 559–572
Broerse JJ, Engles CA, Lelieveld P, van Putten LM, Duncan W, Greene D, Massey JB, Gilbert CW, Hendry JH, Howard A (1971) The survival of colony-forming units in mouse bone marrow after in vivo irradiation with D-T neutrons, x- and gamma radiation. Int J Radiat Biol 19: 101–110
Carsten AL, Bond VP, Thompson K (1976) The RBE of different energy neutrons as measured by the hematopoietic spleen-colony technique. Int J Radiat Biol 29: 65–70
Duncan W, Greene D, Howard A, Massey JB (1969) The RBE of 14 MeV neutron observations on colony forming units in mouse bone marrow. Int J Radiat Biol 15: 397–403
Fairchild RG, Atkins HL, Drew RM, Robertson JS (1974) Biological effects of252Cf neutrons. Eur J Cancer 10: 305–308
Feola J, Nava CA, Maruyama Y (1982) Biological effects of cf-252 neutrons at low dose rates. Int J Radiat Biol 41: 33–46
Frindel E, Hahn GM, Robaglin D, Tubiana M (1972) Responses of bone marrow and tumor cells to acute and protracted irradiation. Cancer Res 32: 2096
Fu KK, Phillips TL, Rowe JR (1974) The RBE of neutrons in vivo. Cancer 34: 48–53
Fu KK, Phillips TL, Kane LJ, Smith V (1975) Tumor and normal tissue responses to radiation at low dose rates. Radiology 114: 709–716
Hendry JH, Baarli J, Bianchi M, Sullivan AH (1979) The effect of a 600 MeV neutron beam on mouse bone marrow. Int J Radiat Biol 35: 393–397
Hendry JH, Howard A (1971) The response of hemopoietic colony forming units to single and split doses ofγ-rays or D-T neutrons. Int J Radiat Biol 19: 51–64
Krebs JS, Jones DCL (1972) The LD50 and the survival of bone marrow colony-forming cells in mice: Effect of rate of exposure to ionizing radiation. Radiat Res 51: 374–380
Maruyama Y (1979) Rapid clearance of advanced pelvic carcinoma by low dose rate Californium Cf-252 neutron therapy. Radiology 133: 473–475
Maruyama Y, Beach JL, Feola JM (1980) Scheduling of hypoxic tumor therapy using neutron brachytherapy. Radiology 137: 775–781
Maruyama Y, Chin HW, Young AB, Bean J, Tibbs P, Beach JL (1982) Cf-252 neutron brachytherapy for hemispheric malignant gliomas. Radiology 145: 171–174
Maruyama Y, Eichten JG (1968) Radiosensitivity of spleen cells irradiated in vitro and in vivo. Am J Roentgenol Radiat Ther Nucl Med 102: 46–52
Maruyama Y, Eichten JG (1969) Hemopoietic colony-forming cells of the spleen. J Minn Acad Sci 35: 104–106
Maruyama Y, Feola JM, Tai D, van Nagell JR, Wilson LC, Yoneda J (1978) Californium-252 for pelvic radiotherapy. Oncology 35: 172–178
Phillips TL, Barshall HH, Goldberg E, Fu K, Rowe J (1977) Comparison of 15 MeV neutrons for damage to an experimental tumor and some normal tissue. Eur J Cancer 10: 287–292
Schneider DO, Whitmore GF (1963) Comparison effects of neutrons and x-rays on mammalian cells. Radiat Res 18: 286–306
Silini G, Maruyama Y (1966) X-ray and fast neutron survival response of 5-BCDR treated mouse marrow cells. Int J Radiat Biol 9: 605–610
Silini G, Maruyama Y, Pozzi L (1965) Efficacia biologica relativa di neutron veloci per l'inattivazione delle cellule emopoietiche del midollo osseo. Radiol Med 51: 515–527
Siminovitch L, Till JE, McCulloch EA (1965) Radiation response of hemopoietic colony-forming cells derived from different sources. Radiat Res 24: 482–493
Todd P, Feola J, Maruyama Y (1982) Survival of cultured human cells exposed to Cf-252 radiation at low dose rate. Int J Radiat Oncol Biol Phys 7: 1293
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Supported by grants from the Kircher Foundation, University of Kentucky Research Foundation and the U.S. Department of Energy
Visiting Scholar, Peking Institute for Cancer Research, People's Republic of China
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Maruyama, Y., Feola, J.M., Hwang, H.N. et al. RBE of spleen CFU-S to low dose rate Cf-252 neutron or photon radiation. Radiat Environ Biophys 21, 265–274 (1983). https://doi.org/10.1007/BF01341463
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DOI: https://doi.org/10.1007/BF01341463