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Studies on incorporated short-livedβ-emitters with regard to the induction of late effects

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Summary

The rare earth radionuclides177Lu and153Sm were administered as single i.p. injections in NMRI mice. Lu was deposited principally (up to 60%) in the skeleton if the quantity of stable carrier was low. Increase of stable carrier enhanced deposition in the reticulo-endothelial system. Sm was preferentially deposited in the liver; the liver deposits were further increased by the addition of stable Sm. Liver doses of between 75 and 150 Gy, resulting from a single injection of153Sm together with 2 mg/kg stable carrier, led to severe lesions in the liver five months after treatment.

Administration of177Lu resulting in skeletal doses of between 28 and 224 Gy was found to be osteosarcomogenic. Up to 40% osteosarcoma incidence was obtained in animals with 56 and 112 Gy doses in the skeleton. Skeletal doses of this order of magnitude are also known to be osteosarcomogenic when given as90Sr injections. The analogous situation withα-emitters is discussed.

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References

  1. Bauer, G. C. H., Carlsson, A., Lindquist, B.: Impairment in incisor teeth formation following administration of high activity32P in weanling rats. Acta Radiol.48, 97–100 (1957)

    Google Scholar 

  2. Durbin, P. W.: Metabolic characteristics within a chemical family. Health Physics2, 225–238 (1960)

    Google Scholar 

  3. Finkel, M. P., Biskis, B. O.: Experimental induction of osteosarcomas. Progr. Exp. Tumor Res.10, 72–111 (1968)

    Google Scholar 

  4. Freemann, L. M., Johnson, P. M.: Clinical Scintillation Imaging. New York: Grune & Stratton 1975

    Google Scholar 

  5. Gössner, W., Hug, O., Luz, A., Müller, W. A.: Experimental induction of bone tumors by short-lived bone-seeking radionuclides. Recent Results Cancer Res.54, 36–49 (1976)

    Google Scholar 

  6. Hindringer, B., Büsing, G.: Schnelleinbettung unentkalkter Knochen von Mäusen für autoradiografische Untersuchungen kurzlebiger wasserlöslicher Isotope durch ein Kontaktverfahren mit AR 10 Strippingfilm. Histochemie26, 333–342 (1971)

    Google Scholar 

  7. ICRP: Report of the RBE committee. Health Physics9, 357–384 (1963)

    Google Scholar 

  8. ICRP Publication 11: A review of the radiosensitivity of tissues in bone. Oxford, London, New York: Pergamon Press 1968

    Google Scholar 

  9. Kyker, G. C., Christopherson, W. M., Berg, H. F., Brucer, M.: Selective irradiation of lymph nodes by radiolutetium (177Lu). Cancer9, 489–498 (1956)

    Google Scholar 

  10. Magnusson, G.: The behavior of certain lanthanons in rats. Acta Pharmacol. Toxicol.20, Suppl. 3, 2–95 (1963)

    Google Scholar 

  11. O'Mara, R. E., McAfee, J. G., Subramanian, G.: Rare earth nuclides as potential agents for skeletal imaging. J. Nucl. Med.10, 49–51 (1969)

    Google Scholar 

  12. Marinelli, L. D.: A revised estimate of maximum permissible burden for Sr-90 in Delayed effects of bone-seeking radionuclides. C. W. Mays et al. (eds.). University of Utah Press, Salt Lake City, pp. 409–416 (1969)

    Google Scholar 

  13. Müller, W. A.: Studies on short-lived internalα-emitters in mice and rats. Part 1.224Ra. Int. J. Radiat. Biol.20, 27–38 (1971)

    Google Scholar 

  14. Müller, W. A., Gössner, W., Hug, O., Luz, A.: Late effects after incorporation of the short-livedα-emitters224Ra and227Th in mice. Health Physics35, 33–55 (1978)

    Google Scholar 

  15. Müller, W. A., Linzner, U., Schäffer, E. H.: Organ distribution studies of Lutetium-177 in mouse. Int. J. Nucl. Med. Biol.5, 29–31 (1978)

    Google Scholar 

  16. Müller, W. A., Luz, A.: The osteosarcomogenic effectiveness of the short-lived224Ra compared with that of the long-lived226Ra in mice. Radiat. Res.70, 444–448 (1977)

    Google Scholar 

  17. Parmley, W. W., Jensen, J. B., Mays, C. W.: Skeletal self-absorption ofβ-particle energy. In: “Some Aspects of Internal Irradiation”. Dougherty T. F. (ed.), pp. 437–453. Oxford, London, New York: Pergamon Press 1962

    Google Scholar 

  18. Rosenblatt, L. S., Hetherington, N. W., Goldmann, M., Bustad, L. K.: Evaluation of tumor incidence following exposure to internal emitters by application of the logistic dose-response surface. Health Physics21, 869–875 (1971)

    Google Scholar 

  19. Spode, E., Gensicke, F.: Über den Stoffwechsel von Radiosamarium (153Sm) in der weiβen Maus. Naturwissenschaften47, 542 (1960)

    Google Scholar 

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Authors and Affiliations

  1. Abteilung Pathologie der Gesellschaft für Strahlen- und Umweltforschung mbH, D-8042, Neuherberg, München, Federal Republic of Germany

    W. A. Müller, E. H. Schäffer & U. Linzner

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  1. W. A. Müller
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  2. E. H. Schäffer
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  3. U. Linzner
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Dedicated to Prof. Dr. Wolfgang Gössner on the occasion of his 60th birthday

In Association with EURATOM (Contr. Nr. 218-76-1)

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Müller, W.A., Schäffer, E.H. & Linzner, U. Studies on incorporated short-livedβ-emitters with regard to the induction of late effects. Radiat Environ Biophys 18, 1–11 (1980). https://doi.org/10.1007/BF01324368

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  • DOI: https://doi.org/10.1007/BF01324368

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