Summary
The colony-forming ability of cultured mammalian cells exposed to monochromatic ultrasonic vibrations of different frequencies (0.1, 0.5, 1.0, 2.0, 3.3 MHz) was studied. The combined effect of x rays and 1.0-MHz ultrasonic waves on the survival of M3-1 cells was also investigated. Split-dose experiments showed that cells exposed to ultrasound are “sensitized” to a subsequent exposure. Almost twice as many cells survive a given ultrasonic dose when exposed in the M phase as when exposed in the S phase. A small amount of synergism between ultrasound and x rays has been observed. The extent of synergism depends on the experimental factors, and may be due to an interaction between nuclear damage caused by x rays and the damage to the cell membrane caused by ultrasound.
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Research supported by the U.S. Atomic Energy Commission and the National Aeronautics and Space Administration
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Martins, B.I., Raju, M.R., Hayes, T.L. et al. Survival of cultured mammalian cells exposed to ultrasound. Radiat Environ Biophys 14, 243–250 (1977). https://doi.org/10.1007/BF01323943
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DOI: https://doi.org/10.1007/BF01323943