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Mammary blood flow and cardiac output in the conscious lactating rabbit

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Summary

  1. 1.

    Cardiac output and regional blood flow were measured in conscious lactating and non-lactating rabbits.

  2. 2.

    At 14 days post-partum the cardiac output in lactating rabbits was 30% higher than that measured in virgin animals.

  3. 3.

    The mammary gland was the only organ to show an increase in relative weight (% body weight) during lactation and also the only organ to receive an increased proportion of the cardiac output per g tissue weight during lactation.

  4. 4.

    These results are discussed in the context of net substrate uptake by the lactating rabbit mammary gland.

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References

  • Bickerstaffe, R., Annison, E.F., Linzell J.L.: The metabolism of glucose, acetate, lipids and amino acids in lactating dairy cows. J. Agric. Sci.82, 71–85 (1974)

    Google Scholar 

  • Caffrey, M., Kinsella, J.E.: Experimental difficulties in assaying a membrane-bound acetyltransferase from rabbit mammary gland. Int. J. Biochem.8, 39–51 (1977)

    Google Scholar 

  • Chatwin, A.L., Linzell, J.L., Setchell, B.P.: Cardiovascular changes during lactation in the rat. J. Endocrinol.44, 247–254 (1969)

    Google Scholar 

  • Davis, S.R., Bickerstaffe, R.: Mammary glucose uptake in the lactating ewe and the use of methionine arteriovenous difference for the calculation of mammary blood flow. Aust. J. Biol. Sci.31, 133–140 (1978)

    Google Scholar 

  • Fegler, G.: Measurement of cardiac output in anaesthetized animals by a thermodilution method. Q.J. Exp. Physiol.39, 153–164 (1954)

    Google Scholar 

  • Hanwell, A., Linzell, J.L.: Validation of the thermodilution technique for the estimation of cardiac output in the rat. Comp. Biochem. Physiol.41A, 647–657 (1972)

    Google Scholar 

  • Hanwell, A., Linzell, J.L.: The time course of cardiovascular changes in lactation in the rat. J. Physiol. (London)233, 93–109 (1973)

    Google Scholar 

  • Jones, C.S., Parker, D.S.: Uptake of substrates for milk-fat synthesis by lactating-rabbit mammary gland. Biochem. J.174, 291–296 (1978)

    Google Scholar 

  • Linzell, J.L.: Mammary-gland blood flow and oxygen, glucose and volatile fatty acid uptake in the conscious goat. J. Physiol. (London)153, 492–509 (1960)

    Google Scholar 

  • Linzell, J.L.: Mammary blood flow and methods of identifying and measuring precursors of milk. In: Lactation, Vol. 1, Larson, B.L., Smith, V.L. (eds.), pp. 143–225. New York, London: Academic Press 1974

    Google Scholar 

  • Linzell, J.L., Mepham, T.B., Annison, E.F., West, C.E.: Mammary metabolism in lactating sows: arteriovenous differences of milk precursors and mammary metabolism of [14C] glucose and [14C] acetate. Br. J. Nutr.23, 319–332 (1969)

    Google Scholar 

  • Lu, M.-H., Anderson, R.R.: Growth of the mammary gland during pregnancy and lactation in the rabbit. Biol. Reprod.9, 538–543 (1974)

    Google Scholar 

  • Matthews, B.F.: Growth of the kidneys in the lactating mouse. J. Physiol. (London)277, 52–53P (1978)

    Google Scholar 

  • Neutze, J.M., Wyler, F., Rudolph, M.: Use of radioactive microspheres to assess distribution of cardiac output in rabbits. Am. J. Physiol.215, 486–495 (1968)

    Google Scholar 

  • Ota, K., Peaker, M.: Lactation in the rabbit: Mammary blood flow and cardiac output. Q. J. Exp. Physiol.64, 225–238 (1979)

    Google Scholar 

  • Reynolds, M.: Udder blood flow in unanaesthetized lactating goats measured with nitrous oxide. Am. J. Physiol.209, 669–672 (1965)

    Google Scholar 

  • Rosenfeld, C.R.: Distribution of cardiac output in ovine pregnancy. Am. J. Physiol.232, H231–235 (1977)

    Google Scholar 

  • Sapirstein, L.A.: Fractionation of the cardiac output of rats with isotopic potassium. Circ. Res.4, 689–691 (1956)

    Google Scholar 

  • Sapirstein, L.A.: Regional blood flow by fractional distribution of indicators. Am. J. Physiol.193, 161–168 (1958)

    Google Scholar 

  • Setchell, B.P., Linzell, J.L.: Soluble indicator techniques for tissue blood flow measurement using86Rb-rubidium chloride, urea, antipyrine (phenazone) derivatives or3H-water. Clin. Exp. Pharmacol. Physiol. Suppl.1, 15–29 (1974)

    Google Scholar 

  • Smith, H.C., Waites, G.M.H.: Blood flow in the brain and reproductive organs of the conscious rabbit before and after ovulation. Aust. J. Exp. Biol. Med. Sci.47, P25 (1969)

    Google Scholar 

  • Smith, N.E., Baldwin, R.L.: Effects of breed, pregnancy and lactation on weight of organs and tissues in dairy cattle. J. Dairy Sci.57, 1055–1060 (1974)

    Google Scholar 

  • Strong, C.R., Dils, R.: Fatty acids synthesised by mammary gland slices from lactating guinea pig and rabbit. Comp. Biochem. Physiol.43B, 643–652 (1972)

    Google Scholar 

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Authors and Affiliations

  1. Department of Physiology and Biochemistry, The University, Whiteknights, RG6 2AJ, Reading, Berkshire, England

    Colin S. Jones & David S. Parker

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  1. Colin S. Jones
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  2. David S. Parker
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Jones, C.S., Parker, D.S. Mammary blood flow and cardiac output in the conscious lactating rabbit. J Comp Physiol B 138, 31–34 (1980). https://doi.org/10.1007/BF00688732

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  • DOI: https://doi.org/10.1007/BF00688732

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