Summary
Thyroidal iodine metabolism in the hypophysectomized snake,Elaphe taeniura, was examined in vivo and in vitro using125I. Hypophysectomy decreased, and TSH increased, both in vivo and in vitro thyroidal accumulation and uptake of radioiodine, and the amount of all labelled substances in the thyroid gland. The operation also altered the distribution of the relative amounts of labelled iodoamino acids in vivo, but not in vitro; nor was there any effect on release of these labelled substances in vitro. In view of the paucity of information available on poikilothermic species, the data are discussed in relation to those of hypothysectomized rats.
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Abbreviations
- DIT :
-
diiodotyrosine
- KRPG :
-
Krebs-Ringer-phosphate solution, containing glucose
- MIT :
-
monoiodotyrosine
- PTU :
-
propylthiouracil
- T 4 :
-
thyroxine
- TSH :
-
thyroid stimulating hormone
References
Ahn, C.S., Rosenberg, I.N.: Prompt stimulation of the organic binding of iodine in the thyroid by adenosine 3′, 5′-phosphate in vivo Proc. Natl. Acad. Sci.60, 830–835 (1968)
Barker, S.B.: Chemical assay of thyroxine-like materials. In: Methods in hormone research, Vol. 1. Dorfman, R.I. (ed.), pp. 411–417. New York: Academic Press 1968
Chiu, K.W., Lynn, W.G.: Solughing and the hypophysis in the glossy snake,Arizona elegans. Am. Mid. Nat.84, 554–560 (1970)
Chiu, K.W., Lynn, W.G., Leichner, J.P.: Environmental temperature and thyroid activity in the lizard,Sceloporus occidentalis. Biol. Bull.139, 107–114 (1970)
Chiu, K.W., Phillips, J.G.: The effect of hypophysectomy and of injections of thyrotropin and corticotropin into hypophysectomized animals on the sloughing cycle of the lizard,Gekko gecko L. J. Endocrinol.49, 611–618 (1971a)
Chiu, K.W., Phillips, J.G.: The effect of prolactin on the sloughing cycle in the hypophysectomized-thyroidectomized lizard,Gekko gecko. J. Endocrinol.49, 619–624 (1971b)
Chiu, K.W., Wong, C.C., Lei, F.H., Tam, V.: The nature of thyroidal secretions in reptiles. Gen. Comp. Endocrinol.25, 74–82 (1975)
Drager, G.A.: A technique for the hypophysectomy of the snake. Texas Rep. Biol. Med. 7, 468–470 (1949)
Greer, M.A., Haibach, H.: Thyroid secretion. In: Handbook of physiology, Vol. 3. Greep, R.O., Astwood, E.B. (eds.), pp. 135–146. Washington, D.C.: American Physiological Society 1974
Greer, M.A., Shimoda, S.I., Rockie, C.: Differential effect of propylthiouracil on in vitro iodoamino acid synthesis by thyroid lobes from intact or hypophysectomized rats. Endocrinology83, 592–595 (1968)
Greer, M.A., Allen, C.F., Torresani, J., Roques, M., Lissitzky, S.: TSH stimulation of iodothyronine formation in prelabelled thyroglobulin of hypophysectomized rats. Endocrinology94, 1224–1231 (1974)
Licht, P.: Endocrinology of reptilians — the pituitary system. In: Chemical zoology, Vol. 9. Florkin, M., Scheer, B.T. (eds.), pp. 399–448. New York: Academic Press 1974
Licht, P., Rosenberg, L.L.: Presence and distribution of gonadotropin and thyrotropin in the pars distalis of the lizardAnolis carolinensis. Gen. Comp. Endocrinol.13, 439–454 (1969)
Lynn, W.G.: The thyroid. In: Biology of reptiles, Vol. 3. Gans, C., Parsens, T.S. (eds.), pp. 201–234. New York: Academic Press 1970
Nussbaum, N.: Hypophysectomy and thyroid function inAnolis (Iguanidae). Anat. Rec.145, 340 (1963)
Pons, G., Biciotti, M., Mazzi, V., Peyrot, A.: Effects of graded hypophysectomy on the thyroid metabolism in the newt. Boll. Zool.39, 383–391 (1972)
Purves, H.D.: Control of thyroid function. In: The thyroid gland, Vol. 2. Pitt-Rivers, R., Trotter W.R. (eds.), pp. 1–38 London: Butterworths 1964
Rosenberg, L.L., Cavalieri, R.R.: Studies of thyroglobulin of the hypophysectomized rats. I. Sensitivity to the disaggregating influences of alkali and low ionic strength. Endocrinology84, 1322–1329 (1969)
Shimoda, S.I., Greer, M.A.: Effect of temperature, pH and time of incubation on the radioiodine metabolism of whole rat thyroid lobes incubated in vitro. Endocrinology75, 698–705 (1964)
Taurog, A.: Biosynthesis of iodoamino acids. In: Handbook of physiology, Vol. 3. Greep, R.O., Astwood, E.B. (eds.), pp. 101–133. Washington, D.C.: American Physiological Society 1974
Taurog, A., Tong, W., Chaikoff, I.L.: Thyroidal131I metabolism in the absence of the pituitary: the untreated, hypophysectomized rat. Endocrinology62, 646–663 (1958a)
Taurog, A., Tong, W., Chaikoff, I.L.: Thyroidal131I metabolism in the absence of the pituitary: the hypophysectomized rat treated with thyrotropic hormone. Endocrinology62, 664–676 (1958b)
Thiele, J., Hehrmann, R., Reale, E.: Freeze-fracture of thyroid follicle cells under different function conditions. In: Biochemical basis of thyroid stimulation and thyroid hormone action. Mühlen, A. von zur, Schleusener, H. (eds.), pp. 101–114. Stuttgart: Georg Thieme Publ. 1976
Wong, C.C.: In vitro effect of TSH on turtle thyroid. Am. Zool.15, 799 (1975)
Yukimura, Y., Ikejiri, K., Kojima, A., Yamada, T.: Effects of excess iodide and other anions on thyroid hormone secretion in normal or hypophysectomized rats treated with graded doses of thyroid hormone. Endocrinology99, 541–548 (1976)
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Wong, C.C., Chiu, K.W. The snake thyroid gland V. effects of hypophysectomy on iodine metabolism in the striped racer,Elaphe taeniura . J Comp Physiol B 131, 297–302 (1979). https://doi.org/10.1007/BF00688804
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DOI: https://doi.org/10.1007/BF00688804