Summary
Experiments in batch-fermenters have demonstrated that the 11β- and 19-hydroxylation of Reichstein's Substance S by Pellicularia filamentosa ceases in the absence of glucose. The effects of glucose consumption rate and growth rate on hydroxylation have been investigated using chemostat cultures. With glucose-limited cultures, increased hydroxylation rates were observed with increased glucose consumption rates. With nitrogen-limited cultures, however, some form of glucose-repression exists. The maximum rate of hydroxylation occurred at a glucose consumption rate at which the culture was just nitrogen-limited. The growth rate had no major importance.
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Clark, T.A., Maddox, I.S. & Chong, R. The effect of glucose on 11β- and 19-hydroxylation of reichstein's substance S by Pellicularia filamentosa . European J. Appl. Microbiol. Biotechnol. 17, 211–215 (1983). https://doi.org/10.1007/BF00510417
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DOI: https://doi.org/10.1007/BF00510417