Skip to main content
SpringerLink
Log in

Kidney alloantigens determined by two regions of the rat major histocompatibility complex

  • Original Investigations
  • Published:
Immunogenetics Aims and scope Submit manuscript

Abstract

Recombination inH-1, the major histocompatibility complex (MHC) of the rat, has defined two regions,H-1A andH-1B, which determine antigens apparently homologous to the KJD and Ia antigens of the mouse, respectively. Alloantisera directed at these antigens have been absorbed with kidney homogenates. The results showed that cells in the kidney express serologically detectable MHC antigens determined by both theH-1A andH-1B region. Control absorptions indicated that to account for these results in terms of recirculating lymphocytes, two perfused kidneys would need to contain more than 60 percent of the recirculating lymphocyte pool. It appears likely, therefore, that H-1B antigens are expressed by cells resident in the kidney.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Barclay, A.N., Letarte-Muirhead, M., Williams, A.F., and Faulkes, R.A.: Chemical characterization of the Thy-1 glycoproteins from the membranes of rat thymocytes and brain.Nature 263:563–561, 1976

    PubMed  Google Scholar 

  • Butcher, G.W. and Howard, J.C.: A recombinant in the major histocompatibility complex of the rat.Nature 266:362–364, 1977

    PubMed  Google Scholar 

  • Chisholm, P.M., Smith, M.E., Sparshott, S.M., and Ford, W.L.: A comparison of immune responses against Ag-B and non-Ag-B antigens, presented alone or together.Transplantation 23:470–418, 1977

    PubMed  Google Scholar 

  • Cramer, D.V., Shonnard, J.W., and Gill, T.J., III: Genetic studies in inbred rats. II. Relationship between the major histocompatibility complex and mixed lymphocyte reactivity.J. Immunogenetics 1:421–428, 1974

    Google Scholar 

  • David, C.S., Shreffler, D.C., and Frelinger, J.A.: New lymphocyte antigen system (Lna) controlled by theIr region of the mouseH-2 complex.Proc. Natl. Acad. Sci. U.S.A. 70:2509–2514, 1973

    PubMed  Google Scholar 

  • Davies, D.A.L.: The true mechanism of immunological enhancement deduced from studies of heart transplants in rats.Transplant. Proc. 8:37–39, 1976

    PubMed  Google Scholar 

  • Davies, D.A.L. and Alkins, B.J.: What abrogates heart transplant rejection in immunological enhancement?Nature 247:294–297, 1974

    PubMed  Google Scholar 

  • Davies, H.ff.S., Taylor, J.E., Daniel, M.R., and Wakerley, C.: Differences between pig tissues in the expression of major transplantation antigens: possible relevance for organ allografts.J. Exp. Med. 143:987–992, 1976

    PubMed  Google Scholar 

  • Davies, H.ff.S., Taylor, J.E., White, D.J.G., and Binns, R.M.: Major transplantation antigens of pig kidney and liver: comparisons between the whole organs and their parenchymal constituents.Transplantation, in press, 1978

  • Delovitch, T.L. and McDevitt, H.O.: Isolation and characterization of murine Ia antigens.Immunogenetics 2:39–52, 1975

    Google Scholar 

  • Fathman, C.G., Cone, J.L., Sharrow, S.O., Tyrer, H., and Sachs, D.H.: Ia alloantigen(s) detected on thymocytes by use of a fluorescence-activated cell sorter.J. Immunol. 115:584–589, 1975

    PubMed  Google Scholar 

  • Fellous, M., Erickson, R.P., Gachelin, G., and Jacob, F.: The time of appearance of Ia antigens during spermatogenesis in the mouse.Transplantation 22:440–444, 1976

    PubMed  Google Scholar 

  • Ford, W.L. and Hunt, S.V.:In D.M. Weir (ed.):Handbook of Experimental Immunology, 2nd edition, Chapter 23. Blackwell, Oxford, 1972

    Google Scholar 

  • Frelinger, J.A., Niederhuber, J.E., David, C.S., and Shreffler, D.C.: Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.J. Exp. Med. 140:1273–1284, 1974

    PubMed  Google Scholar 

  • Gill, T.J., III, Kunz, H.W., Shonnard, J.W., Davis, B.K., and Hansen, C.T.: Immunogenetic studies of the recombinant B3 strain of rats.Transplant. Proc. 9:567–573, 1977

    PubMed  Google Scholar 

  • Götze, D., Reisfeld, R.A., and Klein, J.: Serological evidence for antigens controlled by theIr region in mice.J. Exp. Med. 138:1003–1008, 1973

    Google Scholar 

  • Gowans, J.L. and Knight, E.J.: The route of re-circulation of lymphocytes in the rat.Proc. Roy. Soc. B. 159:251–282, 1964

    Google Scholar 

  • Hämmerling, G.J., Mauve, G., Goldberg, E., and McDevitt, H.O.: Tissue distribution of Ia antigens: Ia on spermatozoa, macrophages, and epidermal cells.Immunogenetics 1:428–437, 1975

    Google Scholar 

  • Hauptfeld, V., Klein, D., and Klein, J.: Serological identification of anIr-region product.Science 181:161–169, 1973

    PubMed  Google Scholar 

  • Howard, J.C. and Scott, D.W.: The identification of sera distinguishing marrow-derived and thymus-derived lymphocytes in the rat thoracic duct.Immunology 27:903–922, 1974

    PubMed  Google Scholar 

  • Jackson, D.C., Parish, C.R., McKenzie, I.F.C.: Detection and isolation of an Ia glycoprotein antigen from mouse serum.Immunogenetics 4:267–279, 1977

    Google Scholar 

  • Klein, J., Chiang, C., Lofgreen, J., and Steinmuller, D.: Participation ofH-2 regions in heart-transplant rejection.Transplantation 22:384–390, 1976

    PubMed  Google Scholar 

  • Marshak, A., Doherty, P.C., and Wilson, D.B.: The control of specificity of cytotoxic T lymphocytes by the major histocompatibility complex (Ag-B) in rats and identification of a new alloantigen system showing no Ag-B restriction.J. Exp. Med. 146:1773–1190, 1977

    PubMed  Google Scholar 

  • Mashimo, S., Sakai, A., Ochiai, T., and Kountz, S.L.: The mixed kidney cell-lymphocyte reaction in rats.Tissue Antigens 7:291–300, 1976

    PubMed  Google Scholar 

  • McKenzie, I.F.C. and Parish, C.R.: Secretion of Ia antigens by a subpopulation of T cells which are Ly-1+, Ly-2− and Ia−.J. Exp. Med. 144:841–851, 1976

    Google Scholar 

  • Parish, C.R., Chilcott, A.B., and McKenzie, I.F.C.: Low molecular-weight Ia antigens in normal mouse serum. I. Detection and production of a xenogeneic antiserum.Immunogenetics 3:113–128, 1976

    Google Scholar 

  • Parish, C.R. and Hayward, J.A.: The lymphocyte surface. II. Separation of Fc receptor, C3 receptor and surface immunoglobulin bearing lymphocytes.Proc. Roy. Soc. B. 187:65–81, 1974

    Google Scholar 

  • Paul, W.E. and Benacerraf, B.: Functional specificity of thymus-dependent lymphocytes.Science 195:1293–1300, 1977

    PubMed  Google Scholar 

  • Radka, S.F., Cramer, D.V., and Gill, T.J., III: Functional properties of an antiserum directed against Ia-like specificities in inbred rats.Fed. Proc. 36:1303, 1977

    Google Scholar 

  • Shinohara, N., Cullen, S.E., and Sachs, D.H.: Ag-B-linked analogue of Ia antigens in the rat.J. Immunol. 118:2083–2087, 1977

    PubMed  Google Scholar 

  • Soulillou, J.P., Carpenter, C.B., d'Apice, A.J.F., and Strom, T.B.: The role of non-classical, Fc receptor-associated Ag-B antigens (Ia) in rat allograft enhancement.J. Exp. Med. 143:405–421, 1976

    PubMed  Google Scholar 

  • Štark, O., Günther, E., Kohoutová, M., and Vojčik, L.: Genetic recombination in the major histocompatibility complex (H-1, Ag-B) of the rat.Immunogenetics 5:183–187, 1977

    Google Scholar 

  • Stuart, F.P., Bastien, E., Holter, A., Fitch, F.W., and Elkins, W.L.: The role of passenger leukocytes in the rejection of renal allografts.Transplant. Proc. 3:461–464, 1971

    PubMed  Google Scholar 

  • Welsh, K.I., Burgos, H., and Batchelor, J.R.: The immune response to allogeneic rat platelets: Ag-B antigens in matrix form lacking Ia.Eur. J. Immunol. 7:267–272, 1977

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, University of Cambridge, Agricultural Research Council, Institute of Animal Physiology, CB2 4AT, Babraham, Cambridge, UK

    Hugh ff. S. Davies

  2. Institute of Animal Physiology, Agricultural Research Council, CB2 4AT, Babraham, Cambridge, UK

    Geoffrey W. Butcher

Authors
  1. Hugh ff. S. Davies
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Geoffrey W. Butcher
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Davies, H.f.S., Butcher, G.W. Kidney alloantigens determined by two regions of the rat major histocompatibility complex. Immunogenetics 6, 171–181 (1978). https://doi.org/10.1007/BF01563907

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01563907

Keywords

Search

Navigation