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Studies on the H-Y antigen in rats

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Abstract

The H-Y antigen has been studied under a variety of experimental conditions in BN and Lewis rats. The results indicate that 1. graft size is crucially important in determining the fate of male skin isografts on females; 2. H-Y incompatible ear skin grafts survive significantly better than those of trunk origin; 3. prior exposure of females to male lymphoid cells greatly increases their capacity to reject male skin isografts; 4. neonatal castration has no influence on the expression of H-Y; 5. multiparity can induce unresponsiveness to H-Y; and 6. although BN females respond better than do Lewis females to H-Y, the antigen is stronger in Lewis males. These findings are compared with the results of similar experiments conducted with mice.

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Authors and Affiliations

  1. Immunobiology Research Unit, Department of Human Genetics and Pathology, University of Pennsylvania, 19174, Philadelphia, Pennsylvania

    Willys K. Silvers, Gwendolyn Murphy & Timothy W. Poole

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  1. Willys K. Silvers
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  2. Gwendolyn Murphy
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  3. Timothy W. Poole
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Additional information

Submitted in memory of Dr. Joy Palm, member of the Wistar Institute, who pioneered the genetic analysis of histocompatibility in rats.

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Silvers, W.K., Murphy, G. & Poole, T.W. Studies on the H-Y antigen in rats. Immunogenetics 4, 85–100 (1977). https://doi.org/10.1007/BF01575648

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  • DOI: https://doi.org/10.1007/BF01575648

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