References
Barber, E. K., Dasgupta, J. D., Schlossman, S. F., Trevillyan, J. M., and Rudd, C.: The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc Natl Acad Sci USA 86: 3277–3281, 1989
Boyse, E. A., Itakura, K., Stockert, E., Iritani, C. A., and Miura, M.: LyC: a third locus specifying alloantigens exposed only on thymocytes and lymphocytes. Transplantation 11: 351–352, 1971
Connolly, J. M., Potter, T. A., Wormstall, E.-M., and Hansen, T. H.: The Lyt-2 molecule recognizes residues in the class I a3 domain in the allogeneic cytotoxic T-cell response. J Exp Med 168: 325–341, 1988
Dembic, Z., Haas, W., Zamoyska, R., Parnes, J., Steinmetz, M., and von Boehmer, H.: Transfection of the CD8 gene enhances T-cell recognition. Nature 326: 510–511, 1987
Dialynas, D. P. and Fitch, F. W.: Lyt-2-/Lyt-3-variants of a cloned cytolytic T cell line lack an antigen receptor functional in cytolysis. J Exp Med 153: 595, 1981
Emmrich, F., Kanz, L., and Eichmann, K.: Cross-linking of the T-cell receptor complex with the subset-specific differentiation antigen stimulates interleukin 2 receptor expression in human CD4 and CD8 T-cells. Eur J Immunol 17: 529–534, 1987
Evans, G. A., Margulies, D. H., Shykind, B., Seidman, J. G., and Ozato, K.: Exon shuffling: mapping polymorphic determinants on hybrid mouse transplantation antigens. Nature 300: 755–757, 1982
Fleischer, B., Schrezenmeier, H., and Wagner, H.: Function of the CD4 and CD8 molecules on human cytotoxic T lymphocytes: regulation of cell triggering. J Immunol 136: 1625–1628, 1986
Gabert, J., Langlet, C., Zamoyska, R., Parnes, J. R., Pchmitt-Verhulst, A.-M., and Malissen, B.: Reconstitution of the MHC class I specificity by transfer of the T-cell receptor and Lyt-2 genes. Cell: 50: 545–554, 1987
Glasebrook, A. L. and Fitch, F. W.: Alloreactive cloned T-cell lines. I. Interactions between cloned amplifier and cytolytic T-cell lines. J Exp Med 151: 876, 1980
Glasebrook, A. L., Wild, D. B., Marrack, P., Pierres, A., Wall, K. A., Havran, W., Otten, G., Loken, M. R., Pierres, M., Kappler, J., and Fitch, F. W.: Characteristics of the murine antigenic determinant, designated L3T4a, recognized by monoclonal antibody GK 1.5: expression of L3T4a by functional T-cell clones appears to correlate primarily with class II MHC antigen reactivity. Immunol Rev 74: 29, 1983
Gottlieb, P. D., Marshak-Rothstein, A., Auditore-Hargreaves, K., Berkoben, D. B., August, D. A., Roche, R. M., and Benedetto, J. D.: Construction and properties of new Lyt-congenic strains and anti-Lyt-2.2 and anti-Lyt-3.1 monoclonal antibodies. Immunogenetics 10: 545–555, 1980
Hasenkrug, K. J., Cory, J. M., and Stimpfling, J. H.: Monoclonal antibodies defining mouse tissue antigens encoded by the H-2 region. Immunogenetics 25: 136–139, 1987
Hunig, T.: Monoclonal anti-Lyt-2.2 antibody blocks lectin-dependent cellular cytotoxicity of H-2 negative target cells. J Exp Med 159: 537, 1984
Klein, J., Figueroa, F., and David, C. S.: H-2 haplotypes, genes and antigens: second listing. Immunogenetics 17: 553–596, 1983
Ledbetter, J. A. and Herzenberg, L. A.: Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol Rev 47: 63–90, 1979
Ledbetter, J. A., Seaman, W. E., Tsu, T. T., and Herzenberg, L. A.: Lyt-2 and Lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytotoxic activity. J Exp Med 153: 1503–1516, 1981
Ledbetter, J. A., June, C. H., Grosmaire, L. S., and Rabinovitch, P. S.: Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes. Proc Natl Acad Sci USA 84: 1384–1388, 1987
Leo, O., Foo, M., Sachs, D. H., Samelson, L. E., and Bluestone, J. A.: Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci USA 84: 1374–1378, 1987
Liaw, C. W., Zamoyska, R., and Parnes, J. R.: Structure, sequence and polymorphism of the Lyt-2 T cell differentiation gene. J Immunol 137: 1037–1043, 1986
Littman, D. R.: The structure of the CD4 and CD8 genes. Annu Rev Immunol 5: 561–584, 1987
MacDonald, H. R., Glasebrook, A. L., and Cerottini, J.-C.: Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes: Analysis by antibody blocking and selective trypsinization. J Exp Med 156: 1711–1722, 1982
Munakata, T., Schmidt-Ullrich, R., Bertschmann, M., and Eichmann, K.: Role of CD8 (Lyt-2) in cytotoxic T-cell function: Analysis of variants of a cytotoxic T-cell clone with reduced Lyt-2 expression. Scand J Immunol 28: 75–80, 1988
Norment, A. M., Salter, R. D., Parham, P., Englehard, V. H., and Littman, D. R.: Cell-cell adhesion mediated by CD8 and MHC class I molecules. Nature 336: 79, 1988
Ozato, K., Hansen, T. H., and Sachs, D. H.: Monoclonal antibodies to mouse MHC antigens. II. Antibodies to the H-2Ld antigen, the products of a third polypeptide locus of the mouse major histocompatibility complex. J Immunol 125: 2473–2477, 1980
Palladino, M. A., Ranges, G. E., Oettgen, H. F., and Old, L. J.: Functional Relationships of Lyt-2 and Lyt-3 expression and T-cell cytotoxicity: a new model system. Adv Exp Med Biol 184: 355–364, 1984
Potter, T. A., Rajan, T. V., Dick, R. F., II, and Bluestone, J. A.: Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes. Nature 337: 73–75, 1989
Rajan, T. V. and Halay, E. D.: Anti-H-2 hybridoma antibodies as immunoselective agents. I. Isolation of forward and reverse mutations for reactivity with a monoclonal antibody. Immunogenetics 14: 253–262, 1981
Rajan, T. V. and Halay, E. D.: H-2 antigen variants in a cultures heterozygous mouse leukemia cell line. Immunogenetics 10: 411–422, 1980
Saizawa, K., Rojo, J., and Janeway, C. A.: Evidence for a physical association of CD4 and the CD3: a, b T-cell receptor. Nature 328: 260–263, 1987
Salter, R. D., Norment, A. M., Chen, B. P., Clayberger, C., Krensky, A. M., Littman, D. R., and Parham, P.: Polymorphism in the α3 domain of HLA-A molecules affects binding to CD8. Nature 338: 345–347, 1989
Sarmiento, M., Glasebrook, A., and Fitch, W.: IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement. J Immunol 125: 2665–2672, 1980
Shinohara, N. and Sachs, D.: Mouse alloantibodies capable of blocking cytolytic T-cell function. I. Relationship between the antigen reactive with blocking antibodies and the Lyt-2 locus.J Exp Med 150: 432–444, 1979
Swain, S. L.: T cell subsets and the recognition of MHC class. Immunol Rev 74: 129–142, 1983
Takada, S. E. and Engleman, E. G.: Evidence for an association between CD8 molecules and the T-cell receptor complex on cytotoxic T cells. J Immunol 139: 3231–3235, 1987
Van Seventer, G. A. V., van Lier, R. A. W., Spits, H., Ivanyi, P., and Melief, C. J. M.: Evidence for a regulatory role of the T8 (CD8) antigen in ntigen-specific and anti-T3-(CD3-)induced lytic activity of allospecific and anti-T3-(CD3-)induced lytic activity of allospecific CTL clone. Eur J Immunol 16: 1363–1371, 1986
Veillette, A., Bookman, M. A., Horak, E. M., and Bolen, J. B.: The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase. Cell 55: 301–308, 1988
Youn, Hyun J., Harriss, June V., and Gottlieb, Paul D.: Nucleotide sequence analysis of the C.AKR Lyt-2 agene: Structural polymorphism is alleles encoding the Lyt-2.1 T-cell surface alloantigen. Immunogenetics 28: 345–352, 1988a
Youn, H. J., Harriss, J. V., and Gottlieb, P. D.: Structure and expression of the Lyt-3 agene of C.AKR mice. Immunogenetics 28: 353–361, 1988b
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Chu, ZT.E., Kung, J.T., Thomas, C. et al. Isolation and properties of a Lyt-2.1-negative mutant of a Lyt-2.1/Lyt-2.2 CTL line. Immunogenetics 34, 42–51 (1991). https://doi.org/10.1007/BF00212311
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DOI: https://doi.org/10.1007/BF00212311