Abstract
Taq I-generated HLA-DQαrestriction fragment length polymorphism was examined in Japanese patients with narcolepsy. All patients were DR2 positive and shared a 6.0 kb fragment, although this fragment was found only in 54 % of the healthy DR2-positive Japanese. This finding added the DQ αgene to the list of candidates for the possible narcolepsy-susceptibility gene. In contrast, there was no complete association between narcolepsy and DXαrestriction fragment length polymorphism. These findings suggest that a narcolepsy-susceptibility gene is located closer to the DQ locus than to the DX locus.
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Matsuki, K., Maeda, H., Juji, T. et al. Taq I-generated HLA-DQ αpolymorphism in Japanese patients with narcolepsy. Immunogenetics 27, 87–90 (1988). https://doi.org/10.1007/BF00351080
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DOI: https://doi.org/10.1007/BF00351080