Abstract
The ontogeny of I-Ak antigens in murine tissues of nonlymphoid origin has been evaluated by reacting acetone-fixed cryostat sections of embryonic, neonate, and adult tissues with the MoAb 10-2.16 in indirect immunofluorescence. Thymus dendritic cells appear to be the first to express I-Ak antigens which become detectable only after birth in skin Langerhans cells, gastrointestinal epithelium, septal cells in lung alveoli, and some endothelia. The full expression of I-Ak antigens as detected in adult mice is reached only at I month of age.
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Natali, P.G., Nicotra, M.R., Giacomini, P. et al. Ontogeny of murine I-Ak antigens in tissue of nonlymphoid origin. Immunogenetics 14, 359–365 (1981). https://doi.org/10.1007/BF00373316
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DOI: https://doi.org/10.1007/BF00373316