Abstract
Using a segregation analysis we have determined that the cross-reactive response to the DBA/2 tumor P815 by CTL from BALB/c mice immunized with a BALB/c plasmacytoma (MOPC-167) is controlled by a single gene. The gene responsible is closely linked to the dilute coat color locus on chromosome 9. In contrast, the cross-reactive response to the DBA/2 tumor L5178Y by DBA/2 anti-MOPC-167 CTL appears to be controlled by two or more genes.
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Abbreviations
- BXD RI:
-
C57BL/6 × DBA/2 recombinant inbred
- CD2F1:
-
(BALB/c × DBA/2)F1
- CTL:
-
cytotoxic thymus-derived lymphocyte
- IUdR:
-
5′ iododeoxyuridine
- PEC:
-
peritoneal exudate cell
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Russell, J.H., Dobos, C.B., Graff, R.J. et al. Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor. Immunogenetics 14, 263–272 (1981). https://doi.org/10.1007/BF00342195
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DOI: https://doi.org/10.1007/BF00342195