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Cross-reactivity between human and murine lymphocyte antigens

IV. Reactivity of H-2 alloantisera with HLA-A, B antigens

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Abstract

The anti-H-2 alloantiserum D-32 [(BlO.A(2R) × C3H.SW) anti-C3H] is cytolytic to human lymphocytes. Fab2 blocking assays, indirect immunoprecipitation and sequential immunoprecipitation experiments showed that the anti-H-2 alloantiserum D-32 recognizes antigenic determinants which are expressed on the heavy chain of subpopulations of HLA-A, B antigens. These determinants are different from those defining the serological polymorphism of the HLA-A, B, C system, are the same as or spatially close to those recognized by the anti-HLA-A, B monoclonal antibody Q6/64 and are expressed on rabbit, rat or guinea pig lymphocytes.

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Quaranta, V., Pellegrino, M.A., Callahan, G.N. et al. Cross-reactivity between human and murine lymphocyte antigens. Immunogenetics 13, 311–317 (1981). https://doi.org/10.1007/BF00364496

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  • DOI: https://doi.org/10.1007/BF00364496

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