Summary
Sodium fluoride (NaF) is used in the treatment of axial osteoporosis and so is mostly given to old patients. Since its pharmacokinetics has not been studied in the elderly, the pharmacokinetics of an enteric-coated tablet containing 50 mg NaF has been investigated in 15 aged inpatients (aged 65 to 75 y) and 12 young healthy volunteers (aged 21 to 26 y).
The serum AUC of fluoride was 1.7-time higher in older than in younger subjects. There was a strong inverse correlation between the AUC and either body surface area (BSA) or glomerular filtration rate (GFR), both of which were very much lower in the elderly.
This concluded that if efficacy or safety are related to the bioavailability of fluoride, it maybe valuable to adjust the dosage of fluoride accordingly to the GFR and BSA.
Similar content being viewed by others
References
Rich C, Ensink J (1961) Effect of sodium fluoride on calcium metabolism of human beings. Nature 191: 184–185
Hodsman AB, Drost DJ (1989) The response of vertebral bone mineral density during the treatment of osteoporosis with sodium fluoride. J Clin Endocrinol Metab 69: 932–938
Ekstrand J, Alvan G, Boreus LO, Norlin A (1977) Pharmacokinetics of fluoride in man after single and multiple oral doses. Eur J Clin Pharmacol 12: 311–317
Ekstrand J, Ehrnebo M, Boreus LO (1978) Fluoride bioavailability after intravenous and oral administration: importance of renal clearance and urine flow. Clin Pharmacol Ther 23: 329–337
Chaleil D, Mauras Y, Allain P (1986) Oral pharmacokinetics of an enteric-coated sodium fluoride preparation. Trace Elements Medicine 3: 11–13
Chaleil D, Boulard C, Guillaume M, Allain P (1988) Etude pharmacocinétique du fluorure après une administration unique d'Ostéofluor. Thérapie 43: 5–7
Briancon D, Quillet P, Duplan B, Chapuy MC, Arlot M, Meunier PJ (1988) Comparaison de la biodisponibilité du fluor à la suite de l'administration de fluorure de sodium seul ou en association avec du calcium. Thérapie 43: 107–110
Mamelle N, Meunier PJ, Dusan R, Guillaume M, Martin JL, Gaucher A, Prost A, Ziegler G, Netter P (1988) Risk-benefit ratio of sodium fluoride treatment in primary vertebral osteoporosis. Lancet 2: 361–365
Riggs BL, Hodgson SF, O'Fallon WN, Chao EYS, Wahner HW, Muhs JM, Cedel SL, Melton LJ (1990) Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis. N Engl J Med 12: 802–809
Greenblatt DJ, Divol LM, Abernethy DR, Shader RI (1982) Physiologic changes in old age: relation to altered drug disposition. J Am Geriatr Soc 30: 6–10
Shand DG (1982) Biological determinants of altered pharmacokinetics in the elderly. Gerontology 28: 8–17
Greenblatt DJ, Sellers EM, Schader RI (1982) Drug therapy: drug disposition in old age. N Engl J Med 28: 8–17
Ekstrand J, Ericsson Y, Resell S (1977) Absence of protein bound fluoride from human blood plasma. Arch Oral Biol 22: 229–232
Whitford GM, Pashley DH, Stringer GI (1976) Fluoride renal clearance: a pH-dependent event. Am J Physiol 230: 527–532
Hosking DJ, Chamberlain MJ (1972) Studies in man with 18 F. Clin Sci 42: 153–161
Spencer H, Kramer L, Osis D, Wiatrowski E (1975) Excretion of retained fluoride in man. J Appl Physiol 38: 282–287
Parsons V, Davies C, Ogg CS, Siddiquadi JY, Geode GC (1971) The ionic composition of bone from patients with chronic renal failure and on RDT with special reference to fluoride and aluminium. Proc Eur Dialysis Transplant Ass 8: 139–148
Parkins FM, Tinanoff N, Mouhinho M, Anstey MB, Waziri M (1974) Relationships of human plasma fluoride and bone fluoride to age. Calcif Tissue Res 16: 335–338
Kuo HC, Stamm JW (1975) The relationship of creatinine clearance to serum fluoride concentration and urinary fluoride excretion in man. Arch Oral Biol 20: 235–238
Cowell DC, Taylor WH (1981) Ionic fluoride: a study of its physiological variation in man. Ann Clin Biochem 18: 76–83
Einwag J, Trautner K (1984) Fluoridkonzentration im Serum und Fluoridausscheidung im Urin nach oraler Aufnahme von 530 mg fluorid aus NaF-Lösung. Dtsch Zahnärztl Z 39: 699–704
Trautner K, Siebert G (1986) An experimental study of bioavailability of fluoride from dietary sources in man. Archs Oral Biol 31: 223–228
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Jeandel, C., Lapicque, F., Netter, P. et al. Effect of age on the disposition of sodium fluoride. Eur J Clin Pharmacol 43, 295–297 (1992). https://doi.org/10.1007/BF02333026
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02333026