Summary
The absorption of the two enantiomers of terbutaline, (+)-terbutaline and (-)-terbutaline, and of the racemate, (±)-terbutaline, has been studied in six healthy volunteers using a newly developed intestinal perfusion technique.
The area under the plasma concentration curve for the (-)-enantiomer was more than twice that for the (+)-enantiomer.
The data demonstrate a clear difference in absorption efficiency between (-)- and (+)-terbutaline, but further studies are required to establish whether (-)-terbutaline influences the absorption of (+)-terbutaline.
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Borgström, L., Kennedy, B.M., Nilsson, B. et al. Relative absorption of the two enantiomers of terbutaline after duodenal administration. Eur J Clin Pharmacol 38, 621–623 (1990). https://doi.org/10.1007/BF00278593
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DOI: https://doi.org/10.1007/BF00278593