Summary
The plasma concentration of torasemide was determined as a function of time in 8 patients with impaired renal function (creatinine clearance ⩽25 ml/min). The elimination half-life (1.3 to 3.8 h), the volume of distribution (0.12 to 0.29 l/kg), and the total body clearance (0.02 to 0.10 l/kg·h) were similar to those observed in normal volunteers.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Benet LZ (1979) Pharmacokinetics/pharmacodynamics of furosemide in man: a review. J Pharmacokinet Biopharm 7: 1–27
Don Brown R, Manno JE (1978) ESTRIP, a basic computer program for obtaining initial polyexponential parameter estimates. J Pharm Sci 67: 1687–1691
Ghys A, Denef J, de Suray JM, Gerin M, Georges A, Delarge J, Willems J (1985) Pharmacological properties of the new potent diuretic torasemide in rats and dogs. Arzneimittelforsch 35 [10]: 1520–1526
Lesne M, Clerckx-Braun F, Duhoux P, van Ypersele de Strihou Ch (1982) Pharmacokinetic study of torasemide in humans: An overview of its diuretic effect. Int J Clin Pharmacol Ther Toxicol 20: 382–387
Mirkin BL, Green TP, O'Dea RF (1980) Disposition and pharmacodynamics of diuretics and antihypertensive agents in renal disease. Eur J Clin Pharmacol 18: 109–116
Traeger A, Stein G, Sperschneider H, Keil E (1984) Pharmacokinetic and pharmacodynamic effects of furosemide in patients with impaired renal function. Int J Clin Pharmacol Ther Toxicol 22: 481–486
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dodion, L., Willems, J.L. Study of the elimination kinetics of torasemide, a novel loop diuretic, in renal insufficiency. Eur J Clin Pharmacol 31 (Suppl 1), 49–51 (1986). https://doi.org/10.1007/BF00541467
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00541467