Summary
In a double-blind study the analgesic activity of a new compound, diviminol 100 mg, was compared with that of codeine 60 mg, and a placebo given as single oral doses to three comparable groups of 30, 31 and 32 patients with post-partum pain. The two drugs were very significantly more active than the placebo on comparing both the hourly pain relief scores, and the frequency of satisfactory analgesia. There was no significant difference between the new drug and the reference coumpound. No undesirable side-effects were noted. These results in post-partum pain provide additional evidence that diviminol is a clinically effective analgesic agent.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Azzollini, F., Lodola, E.: Diviminol (Z. 424): a pilot study for prolonged clinical use. Int. J. clin.Pharm. Ther. Toxicol. In press 1970.
Baptisti, A., Jr., Chernish, S.M., Gruber, C.M., Jr.: The use of non-narcotic analgesic drugs in postpartum patients. Arch. int. Pharmacodyn.159, 234–239 (1966).
Beaver, W.T.: Mild analgesics. A review of their clinical pharmacology (PartII). Amer. J. med. Sci.251, 576–599 (1966).
—— Wallenstein, S.L., Houde, R.W., Rogers, A.: A comparison of the analgesic effects of methotrimeprazine and morphine in patients with cancer. Clin. Pharm. Ther.7, 436–446, (1966).
—— —— —— —— A clinical comparison of the analgesic effects of methadone and morphine administered intramuscularly and of orally and parenterally administered methadone. Clin. Pharm. Ther.8, 415–426 (1967).
Buzzelli, G., Grazzini, M., Monafo, V.: A controlled evaluation of the analgesic activity of diviminol (Z. 424) based on the responses to the ischaemic test. Curr. Ther. Res.12, 561–569 (1970).
Capretti, G., Frigerio, G.: Studio clinico controllato dell' attività analgesica di un nuovo farmaco (Z. 424) nel dolore da neoplasie. Clin. Terap.52, 361–369 (1970).
DeKornfeld, T.J., Lasagna, L., Frazier, T.M.: A comparative study of five proprietary analgesic compounds. J.A.M.A.182, 1315–1318 (1962).
Della Bella, D.: Pharmacological report on Z. 424. Zambon Research Laboratories, Bresso (Milan), Italy 1967.
Gruber, C.M., Jr., Baptisti, A., Jr.: Estimating the acceptability of morphine and noracymethadol in postpartum patients. Clin. Pharm. Ther.4, 172–181 (1963).
Houde, R.W., Wallenstein, S.L., Rogers, A.: Clinical pharmacology of analgesics. Clin. Pharm. Ther.1, 163–174 (1960).
Kimball, A.W.: Short-cut formulas for the exact partition of χ2 in contingency tables. Biometrics10, 452–458 (1954).
Lasagna, L.: The clinical measurement of pain. Ann. N.Y. Acad. Sci.86, 28–37 (1960).
Lasagna, L., Davis, M., Pearson, J.W.: A comparison of acetophenetidin and acetaminophen. I. Analgesic effects in postpartum patients. J. Pharmacol. exp. Ther.155, 296–300 (1967).
Martinetti, L., Lodola, E., Monafo, V., Ferrari, V.: Clinical evaluation of an oral analgesic (Z. 424) in patients with chronic pain. J. clin. Pharm.10, 390–399 (1970).
-- Monafo, V.: A clinical study of diviminol on prolonged administration. Int. J. clin. Pharm. Ther. Toxicol. In press 1970.
Procacci, P., Buzzelli, G., Grazzini, M., Monafo, V.: A controlled trial of a new analgesic (Z. 424) in experimental and pathological pain in comparison with codeine and aminopyrine. Curr. Ther. Res.11, 647–656 (1969).
Sevelius, H., Colmore, J.P.: Experimental design for evaluation of non-narcotic analgesic agents. J. New Drugs4, 337–346 (1964).
Snedecor, G.W.: Statistical methods. Ed. 5, Ames, Jowa, Jowa State College Press, 1956.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nobili, F., Bernardi, G.C. Evaluation of a new oral analgesic (diviminol, Z. 424) in post-partum pain. Eur J Clin Pharmacol 3, 119–122 (1971). https://doi.org/10.1007/BF00619305
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00619305