Skip to main content
SpringerLink
Log in

Systolic time intervals during long-term beta-blockade with alprenol in ischaemic heart disease

  • Originals
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Summary

The effect of long-term treatment with alprenolol on left ventricular function was investigated in a controlled double-blind study of 15 patients with ischaemic heart disease (alprenolol 6, placebo 9), by measurement of systolic time intervals (STI). Significant prolongation of QS2I was observed in patients treated with alprenolol (p<0.05), while changes in PEPI, LVETI and PEP/LVET were all insignificant. The heart rate x systolic blood pressure product (RPP) was significantly reduced in the alprenolol group (p<0.05). The data suggest that long-term treatment with alprenolol did not impair left ventricular function as evaluated by STI, and that myocardial oxygen demand, assessed by RPP, was reduced during the treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Reale A, Nigri A, Gioffré PA, Motolese M (1979) Acute influence of different beta-blocking agents upon left heart haemodynamics at rest and during exercise in patients with coronary artery disease. Eur J Cardiol 9: 101–109

    Google Scholar 

  2. Svendsen TL, Carlsen JE, Hartling O, McNair A, Trap-Jensen J (1980) A comparison of the acute haemodynamic effects of propranolol and pindolol at rest and during supine exercise in man. Clin Sci Mol Med 59: 465–468

    Google Scholar 

  3. Svendsen TL, Hartling O, Trap-Jensen J (1979) Immediate haemodynamic effects of propranolol, practolol, pindolol, atenolol and ICI 89,406 in healthy volunteers. Eur J Clin Pharmacol 15: 223–228

    Google Scholar 

  4. Lund-Johansen P (1979) Hemodynamic consequences of long-term beta-blocker therapy: a 5-year follow-up study of atenolol. J Cardiovasc Pharmacol 1: 487–495

    Google Scholar 

  5. Main in 'T Veld AJ, Schalekamp MADH (1982) How intrinsic sympathomimetic activity modulates the haemodynamic responses to beta-adrenoceptor antagonists. A clue to the nature of their antihypertensive mechanism. Br J Clin Pharmacol 13: 245S-257S

    Google Scholar 

  6. Nyberg G (1979) Effect of beta-adrenergic blockade on haemodynamic responses to dynamic and isometric exercise in angina pectoris. Eur J Clin Pharmacol 15: 381–388

    Google Scholar 

  7. Erbel R, Schweitzer P, Wagner G, Merx W, Effert S (1980) Evaluation of long term therapy with propranolol in mitral valve prolapse syndrome. In: List WF, Gravenstein JS, Spodick DH (eds) Systolic time intervals. Springer, Berlin Heidelberg New York, pp 256–264

    Google Scholar 

  8. Andersen MP, Frederiksen J, Bechsgaard P et al (1979) Effect of alprenolol on mortality among patients with definite or suspected myocardial infarction. Lancet 2: 865–868

    Google Scholar 

  9. WHO (1979) Ischaemic heart disease register. Copenhagen

  10. Weissler AM, Lewis RP, Leighton RF (1972) The systolic time intervals as a measure of left ventricular performance in man. In: Yu PN & Goodwin JF (eds) Progress in cardiology. Lea & Febiger, Philadelphia, pp 155–183

    Google Scholar 

  11. Kryger P, Lublin H, Godtfredsen J (1979) Clinical employment of the systolic time intervals (STI). Report of a Danish normal material. Ugeskr Laeg 47: 1749–1752

    Google Scholar 

  12. Lewis RP, Rittgers SE, Forester WF, Boudoulas H (1979) A critical review of the systolic time intervals. Circulation 56: 146–158

    Google Scholar 

  13. Mostri G, Tomei G, Veltri M, Giusti C (1979) The effect of methoprolol on systolic times in patients with stable angina pectoris. Min Cardioangiol 27: 147–152

    Google Scholar 

  14. Boudoulas H, Lewis RP, Kates RE, Dalmangas G, Beaver BM (1980) Usefulness of the systolic time intervals in the study of beta-blocking agents. In: List WF, Gravestein JS, Spodick DH (eds) Systolic time intervals. Springer, Berlin Heidelberg New York, pp 243–255

    Google Scholar 

  15. Garrard CL Jr, Weissler AM, Dodge HT (1970) The relationship of alteration in systolic time intervals to ejection fraction in patients with coronary artery disease. Circulation 45: 529–533

    Google Scholar 

  16. Jorgensen CR, Wang K, Wang Y, Gobell FL, Nelson RR, Taylor H (1973) Effect of propranolol on myocardial oxygen consumption and its hemodynamic correlates during upright exercise. Circulation 48: 1173–1181

    Google Scholar 

  17. Gobel FL, Nordstrom LA, Nelson RR, Jorgensen CR, Wang Y (1978) The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris. Circulation 57: 549–556

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Coronary Care Unit, Medical Department, Sundby Hospital Copenhagen, Denmark

    S. Lind Rasmussen, F. Pedersen & P. B. Nielsen

  2. Laboratory of Cardiology, Amtssygehuset i Gentofte, DK-2900, Hellerup, Denmark

    S. Lind Rasmussen

Authors
  1. S. Lind Rasmussen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Pedersen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. B. Nielsen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rasmussen, S.L., Pedersen, F. & Nielsen, P.B. Systolic time intervals during long-term beta-blockade with alprenol in ischaemic heart disease. Eur J Clin Pharmacol 25, 503–506 (1983). https://doi.org/10.1007/BF00542118

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00542118

Key words

Search

Navigation