Summary
Oral theophylline was given to 6 adults with airways obstruction. The initial dose was 125 mg daily and this was increased by 125 mg each week. The final total daily dose reached was determined by side effects and ranged from 500 mg to 1125 mg. At the end of each week and before the next dosage increment steady state, trough plasma theophylline concentrations were measured. For each individual and for the group as a whole there was a highly significant linear correlation between theophylline dose and trough plasma concentration. This indicates that for oral theophylline, in adults, dose-dependent kinetics do not play a significant role and dose may be adjusted without fear of a disproportionate rise in plasma concentration.
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References
Jenne JW, Wyze E, Rood FS, MacDonald FM (1972) Pharmacokinetics of theophylline. Clin Pharmacol Ther 13: 349–360
Jonkman JHG, Tang DDS, Upton RA, Riegelman S (1981) Measurement of excretion characteristics of theophylline and its major metabolites. Eur J Clin Pharmacol 20: 435–441
Koëter GH, Jonkman JHG, de Vries K, Schoenmaker R, Greving JE, Zeeuw RA (1981) Pharmacokinetics of sustained release theophylline in low and high multidose regimens. Br J Clin Pharmacol 12: 647–652
Lesko LJ (1979) Dose dependent elimination kinetics of theophylline. Clin Pharmacokinet 4: 449–459
Monks TJ, Caldwell CH, Smith RL (1979) Influence of methylxanthine containing foods on theophylline metabolism and kinetics. Clin Pharmacol Ther 26: 513–524
Ogilvie RI (1978) Clinical pharmacokinetics of theophylline. Clin Pharmacokinet 3: 267–293
Ogilvie RI (1981) Theophylline: Clinical aspects. In: Richens A, Marks V (eds) Therapeutic drug monitoring. Churchill Livingstone, Edinburgh London Melbourne New York, pp 425–433
Richens A, Dunlop A (1975) Serum phenytoin levels in management of epilepsy. Lancet 2: 247–248
Sarrazin E, Hendeles L, Weinberger M, Muir K, Riegelman S (1978) Dose-dependent kinetics for theophylline: Observations among ambulatory asthmatic children. J Pediatr 97: 825–828
Shen DD, Fixley M, Azarnoff DL (1978) Theophylline bioavailability following chronic dosing of an elixir and two solid dosage forms. J Pharma Sci 67: 916–919
Sitar DS, Nadeau JH, Ruedy JR (1977) Comparative bioavailability of two oral dosage forms of oxtriphylline. Curr Ther Res 21: 233–239
Tozer TN, Tang-Liu DDS, Riegelman S (1981) Linear vs. nonlinear kinetics. In: Breimer DD, Speiser P (eds) Topics in pharmaceutical sciences. Elsevier/North-Holland Biomedical Press, Amsterdam New York Oxford
Weinberger M, Ginchansky E (1977) Dose-dependent kinetics of theophylline disposition in asthmatic children. J Pediatr 91: 820–824
Zarowitz BJM, Szefler SJ, Lasezkay GM (1981) Effect of erythromycin base on theophylline kinetics. Clin Pharmacol Ther 29: 601–605
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Brown, P.J., Dusci, L.J. & Shenfield, G.M. Lack of dose dependent kinetics of theophylline. Eur J Clin Pharmacol 24, 525–527 (1983). https://doi.org/10.1007/BF00609897
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DOI: https://doi.org/10.1007/BF00609897