Summary
The kinetics of piretanide was studied in patients with renal failure. After oral administration of a high dose of piretanide (96 mg), the pharmacokinetic parameters were: elimination rate constant 0.346±0.072 h−1, half life 2.00±0.35 h, and total plasma clearance 119.55±35.90 ml · min−1. Compared to the values obtained in adults with normal renal function, these results show a decrease in total plasma clearance, but conservation of the metabolic clearance which amounts to 45% of the total clearance in the healthy adult.
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References
Beermann B, Dalen E, Lindstrom B (1977) Elimination of furosemide in healthy subjects and in those with renal failure. Clin Pharmacol Ther 22: 70–78
Cutler RE, Forrey AW, Christopher TG, Kimpel BM (1974) Pharmacokinetics of furosemide in normal subjects and functionally anephric patients. Clin Pharmacol Ther 15: 588–596
Huang CM, Atkinson AJ, Levin M, Levin N, Quintanilla A (1974) Pharmacokinetics of furosemide in advanced renal failure. Clin Pharmacol Ther 16: 659–666
Lawrence JR, Ansari AF, Elliot HL, Summer DJ, Brunton GF, Whiting B, Whitesmith R (1978) Kinetic and dynamic comparison of piretanide and furosemide. Clin Pharmacol Ther 23: 558–565
Marone C, Reubi FC (1980) Effects of a new diuretic (piretanide) compared with furosemide on renal diluting concentrating mechanisms in patients with the nephrotic syndrome. Eur J Clin Pharmacol 17: 165–171
Merkel W, Bormann D, Mania D, Muschaweck R, Hropot M (1976) Piretanide (HOE 118), a new high ceiling salidiuretic. Eur J Med Chem Chim Ther 11: 399–406
Pozet N, Hadj-Aissa A, Pellet M (1980) Activity of a new high efficiency diuretic in man: piretanide (HOE 118). Br J Clin Pharmacol 9: 577–583
Rane A, Villeneuve JP, Stone WJ, Nies AS, Wilkinson GR, Branch RA (1978) Plasma binding and disposition of furosemide in the nephrotic syndrome and in uremia. Clin Pharmacol Ther 24: 199–207.
Rupp W (1974) Pharmacokinetics and pharmacodynamics of lasix. Scott Med J 19: 5–13
Tilstone WJ, Fine A (1978) Furosemide kinetics in renal failure. Clin Pharmacol Ther 23: 644–650
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Brazier, J.L., Pozet, N., Faucon, G. et al. Kinetics of a high dose of piretanide in renal failure. Eur J Clin Pharmacol 21, 307–310 (1982). https://doi.org/10.1007/BF00637618
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DOI: https://doi.org/10.1007/BF00637618