Summary
The pharmacokinetic behaviour and neuromuscular blockade produced by the administration of fazadinium bromide at a dose of 1 mg/kg have been studied in seven patients with end-stage renal failure. No significant differences were found in the pharmacokinetic or pharmacodynamic properties when compared with patients with normal renal function. It is suggested that fazadinium may be superior to either d-tubocurarine or pancuronium in providing muscle relaxation for patients with renal failure.
Article PDF
Similar content being viewed by others
References
Miller RD, Matteo RS, Benet LZ, Sohn YJ (1977) The pharmacokinetics of d-tubocurarine in man with and without renal failure. J Pharmacol Exp Ther 202: 1–7
McLeod K, Watson MJ, Rawlins MD (1976) Pharmacokinetics of pancuronium in patients with normal and impaired renal function. Br J Anaesth 48: 341–345
Somogyi AA, Shanks CA, Triggs EJ (1977) The effect of renal failure on the disposition and neuromuscular blocking action of pancuronium bromide. Eur J Clin Pharmacol 12: 23–29
Cohen EN, Brewer HW, Smith P (1967) The metabolism and elimination of d-tubocurarine-H3. Anesthesiology 28: 309–317
Miller RD, Stevens WC, Way WL (1973) The effect of renal failure and hyperkalaemia on the duration of pancuronium neuromuscular blockade in man. Anesth Analg (Cleve) 52: 661–666
D'Hollander AA, Camu F, Sanders M (1978) Comparative evaluation of neuro-muscular blockade after pancuronium administration in patients with and without renal failure. Acta Anaesth Scand 22: 21–26
Feldman SA, Levi JA (1963) Prolonged paresis following gallamine. Anesth Analg (Cleve) 35: 804–806
Singer MM, Dutton R, Way WL (1971) Untoward results of gallamine administration during bilateral nephrectomy: treatment with haemodialysis. Br J Anaesth 43: 404–408
Churchill-Davidson HC, Way WL, De Jong RH (1967) The muscle relaxants and renal excretion. Anesthesiology 28: 540–546
Geha DG, Blitt CD, Moon BJ (1976) Prolonged neuromuscular blockade with pancuronium in the presence of acute renal failure: a case report. Anesth Analg (Cleve) 55: 343–345
Miller RD, Cullen DJ (1976) Renal failure and postoperative respiratory failure: recurarisation? Br J Anaesth 48: 253–256
Rouse JM, Galley RLA, Bevan DR (1977) Prolonged curarisation following renal transplantation. A retrospective study. Anaesthesia 32: 247–251
Camu F, D'Hollander AA (1978) Neuromuscular blockade of fazadinium bromide (AH 8165) in renal failure patients. Acta Anaesth Scand 22: 221–226
Duvaldestin P, Henzel D, Demetrion M, Desmonts JM (1978) Pharmacokinetics of fazadinium in man. Br J Anaesth 50: 773–777
Bevan DR, D'Souza J, Rouse JM, Caldwell J, Smith RL (1980) Clinical pharmacokinetics of fazadinium. Anaesthesia 35: 873–878
Duvaldestin P, Bertrand JC, Concina C, Henzel D, Lareng L, Desmonts JM (1979) Pharmacokinetics of fazadinium in patients with renal failure. Br J Anaesth 51: 943–947
Ali HH, Utting JE, Gray TC (1970) Stimulus frequency in the detection of neuromuscular block in humans. Br J Anaesth 42: 966–977
D'Souza J, Caldwell J, Dring LG, Rouse J, Bevan DR, Smith RL (1979)125I Labelled Rose Bengal in the quantitative estimation of fazadinium and other quaternary ammonium compounds in biological fluids. J Pharm Pharmcol 31: 416–418
Reigelman S, Loo JCK, Rowland M (1968) Concept of a volume of distribution and possible errors in evaluation of this parameter. J Pharm Sci 57: 117–123
Greenblatt DJ, Koch-Weser J (1975) Clinical pharmacokinetics (first of two parts). N Engl J Med 293: 702–705
Gibaldi M, Levy G, Hayton W (1972) Kinetics of the elimination and neuromuscular blocking effect of d-tubocurarine in man. Anesthesiology 36: 213–218
Kalow W (1959) The distribution, destruction and elimination of muscle relaxants. Anesthisology 20: 505–518
Cohen EN, Corbascio A, Fleischli G (1965) The distribution and fate of d-tubocurarine. J Pharmacol Exp Ther 147: 120–129
Feldman SA, Cohen EN, Golling RC (1969) The excretion of gallamine in the dog. Anesthesiology 30: 593–598
Stovner J, Lund I (1970) The muscle relaxants and their antagonists. Br J Anaesth 42: 235–248
D'Souza J (1980) Metabolic and Disposition Studies of Quaternary Ammonium Compounds in Man and Laboratory Species. Ph D Thesis, University of London
Bevan DR, Caldwell J, D'Souza J, Smith RL (1978) Influence of impaired renal function on the disposition of (14C) fazadinium in the anaesthetised greyhound. Br J Pharmacol 64: 402–403P
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bevan, D.R., Souza, J.D., Rouse, J.M. et al. Clinical pharmacokinetics and pharmacodynamics of fazadinium in renal failure. Eur J Clin Pharmacol 20, 293–298 (1981). https://doi.org/10.1007/BF00618780
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00618780