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Metabolic studies of taloximine and its effects on the respiratory response to carbon dioxide

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Summary

Taloximine is a phthalazine derivative with a respiratory stimulant action on the peripheral chemoreceptors. Peak plasma levels of taloximine after oral administration coincided with peak hyperventilation accompanied by a respiratory alkalosis, a, fall in venous pCO2, and a rise in plasma and urinary pH. — Taloximine was excreted in urine and bile. Metabolites included a phthalazinone, demethylated taloximine and other metabolites in ring hydroxylated form. Sulphated and glucuronated taloximine and metabolites were formed.

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References

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Prime, F., Griffin, J.P., Turner, P. et al. Metabolic studies of taloximine and its effects on the respiratory response to carbon dioxide. Pharmacol. Clin. 2, 155–160 (1970). https://doi.org/10.1007/BF00420343

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  • DOI: https://doi.org/10.1007/BF00420343

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