Summary
Taloximine is a phthalazine derivative with a respiratory stimulant action on the peripheral chemoreceptors. Peak plasma levels of taloximine after oral administration coincided with peak hyperventilation accompanied by a respiratory alkalosis, a, fall in venous pCO2, and a rise in plasma and urinary pH. — Taloximine was excreted in urine and bile. Metabolites included a phthalazinone, demethylated taloximine and other metabolites in ring hydroxylated form. Sulphated and glucuronated taloximine and metabolites were formed.
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Coupar, I.M., Hedges, A., Metcalfe, H.L., Daly, M.J., Lightowler, J.E.: The effects of taloximine and aminophylline on isolated human smooth muscle. Arch. Int. Pharmacodyn. 180, 492–500 (1969).
Daly, M., Lightowler, J.E., Pickering, R.W.: Taloximine, a new respiratory stimulant with bronchodilator properties. Brit. J. Pharmacol. 35, 283–294 (1969).
Pearson, J. A., Griffin, J.P.: Investigations into the site of action of taloximine: a new respiratory stimulant molecule. Experientia 25, 716–717 (1969).
Westlake, E.K., Prime, F.J.: The respiratory response to carbon dioxide. Clin. Sci. 13, 321–332 (1954).
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Prime, F., Griffin, J.P., Turner, P. et al. Metabolic studies of taloximine and its effects on the respiratory response to carbon dioxide. Pharmacol. Clin. 2, 155–160 (1970). https://doi.org/10.1007/BF00420343
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DOI: https://doi.org/10.1007/BF00420343