Summary
Cathodic stripping voltammetry of an adsorbed 6-thiopurine at HMDE was investigated in solutions of varying pH. A rapid and sensitive differential pulse voltammetric method was selected for its trace determination. A method has also been developed for the determination of 6-thiopurine in presence of Cu(II), due to the strong adsorption of the Cu-6-thiopurine complex at the surface of the HMDE and subsequent reduction of the surface-bound complex. A detection limit of 9.9×10−9 mol/l was achieved in presence of Cu(II) and the slope of the straight line was seven times the slope in absence of Cu(II). Cathodic adsorptive stripping (CAS) voltammetry of 6-thiopurine in presence of Ni(II), Pb(II), Cd(II), and Fe(III) was also investigated. The influence of several operational parameters has been considered. Statistical analysis of the calibration curve data is included.
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Elion CB, Bieber S, Hitchings GH (1954) Ann NY Sci 60:297
Nelson JA, Carpenter JW, Rose LM, Adamson DY (1975) Cancer Res 35:2872
Smyth WF, Davidson IE (1980) In: Smyth WF (ed) Electroanalysis in hygiene: Environmental clinical and pharmaceutical chemistry. Elsevier, Amsterdam p 271
Vire JC, Vire JM, Kuffman JM, Patriarch GJ (1982) J Pharm Belg 37:442
Grier RA, Andrews RW (1981) Anal Chim Acta 124:333
Palecek E, Osteryoung J, Osteryoung RA (1982) Anal Chem 54:1389
Palecek E (1980) Anal Biochem 198:129
Florence TM (1979) J Electroanal Chem 97:219
Wang J, Freiha BA (1984) Bioelectrochem Bioenerg 12:235
Kalvoda R (1982) Anal Chim Acta 162:197
Wang J, Luo DB, Farias PAM, Mohmoud JS (1985) Anal Chem 57:158
Glodowski S, Bilewicz R, Kublik Z (1986) Anal Chim Acta 186:39
Parsons R, Symons PC (1968) Trans Faraday Soc 64:1077
Temerk YM, Kamal MM, Ahmed ZA, Ahmed ME, Ibrahim MS (1992) Fresenius J Anal Chem 342:601
Ibrahim MS (1992) Thesis, Chemecal Department, Assiut University, Assiut, Egypt
Temerk YM, Kamal MM, Ahmed ZA, Ibrahim MS (1989) J Electroanal Chem 260:201
Bilewicz R, Muszalska E (1991) J Electroanal Chem 300:147
Dubler E, Gyr E (1988) Inorg Chem 27:1466
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Temerk, Y.M., Ahmed, Z.A., Ahmed, M.E. et al. Cathodic adsorptive stripping voltammetry of 6-thiopurine in absence and presence of some metal ions. Fresenius J Anal Chem 345, 733–736 (1993). https://doi.org/10.1007/BF00325845
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DOI: https://doi.org/10.1007/BF00325845