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FIA titrations of sulphide, cysteine and thiol-containing drugs with chemiluminescent detection

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  • Pharmaceutical/Clinical Analysis
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Summary

The determination of sulphide, cysteine and thiol-containing drugs by high-speed FIA titrations with chemiluminescent detection is described. Two different redox processes, the reduction of hypochlorite by sulphide or thiol-containing drugs and the oxidation of luminol by hypochlorite, were coupled in the same FIA assembly. Procedures were applied to the determination of cysteine, N-acetylcysteine, N-penicillamine, 2-mercaptopropionyl-glycine and thiouracil in pharmaceuticals.

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References

  1. Lukovskaya NM, Markova LV (1969) J Anal Chem USSR 24:1868

    Google Scholar 

  2. Lukovskaya NM, Anatienko NI (1976) Org Reagenty Analit Khim Tezisy Dokl Uses Konf 2:80

    Google Scholar 

  3. Klockow D, Teckentrup J (1976) Talanta 23:889

    Google Scholar 

  4. Burguera JL, Townshend A (1980) Talanta 27:309

    Google Scholar 

  5. Burguera JL, Townshend A, Greenfield S (1980) Anal Chim Acta 114:209

    Google Scholar 

  6. Viñas P, López García I, Martínez Gil JA (1993) J Pharm Biomed Anal (in press)

  7. Goodman GA, Goodman LS, Rall TW, Murad F (1985) The pharmacological basis of therapeutics, 7th edn. Macmillan, New York

    Google Scholar 

  8. Ramsing AU, Ruzicka J, Hansen EH (1981) Anal Chim Acta 129:1

    Google Scholar 

  9. Isacsson U, Wettermark G (1976) Anal Chim Acta 83:227

    Google Scholar 

  10. Marino DF, Ingle JD Jr (1981) Anal Chem 53:455

    Google Scholar 

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, E-30071, Murcia, Spain

    I. López García, P. Viñas & J. A. Martínez Gil

Authors
  1. I. López García
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  2. P. Viñas
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  3. J. A. Martínez Gil
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García, I.L., Viñas, P. & Gil, J.A.M. FIA titrations of sulphide, cysteine and thiol-containing drugs with chemiluminescent detection. Fresenius J Anal Chem 345, 723–726 (1993). https://doi.org/10.1007/BF00325843

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  • DOI: https://doi.org/10.1007/BF00325843

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