Skip to main content
SpringerLink
Log in

Pathomechanisms of the adult respiratory distress syndrome (ARDS): Chemiluminescence analysis of polymorphonuclear leukocytes

Zum Pathomechanismus des posttraumatischen progessiven Lungenversagens (ARDS): Chemilumineszenz-Analyse polymorphkerniger Leukocyten

  • Posters B
  • Markers and Mediators of Inflammation
  • Published:
Fresenius' Zeitschrift für analytische Chemie Aims and scope Submit manuscript

Conclusions

As measured by the luminol enhanced chemiluminescence stimulated by zymosan A the posttraumatic stimulatory response was increased in blood derived and decreased in BAL derived PMNL as compared to normals. This loss of metabolic function is paralleled by an increased extracellular release of respiratory burst products and lysosomal enzymes from stimulated and phagocytosing PMNL during their capillary-interstitial-alveolar passage. These events seem to be part of the pathogenetic mechanisms that contribute to the lung injury in ARDS. The observed shortening of photon emission times is supposed to be caused by C3b receptor affinity and/or concentration increase during the in vivo PMNL stimulation and migration across the blood/air barrier as a result of the attempt to compensate for the disappearing response ability.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abbreviations

PTS :

polytrauma scale ≙ injury severity score (ISS)

PBS :

phosphate buffered saline

MEM :

minimal essential medium

References

  1. Allen RC, Stjernholm RL, Steele RH (1972) Biochem Biophys Res Commun 47:679

    Google Scholar 

  2. Schraufstatter I, Revak SD, Cochrane CG (1984) Fed Proc 43:2807

    Google Scholar 

  3. Tate RM, Repine JE (1983) Am Rev Resp Dis 128 (3):552

    Google Scholar 

  4. Worthen GS, Henson PM (1983) Clin Lab Med 3:601

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Abteilung für Klinische Biochemie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, D-3000, Hannover 61, Federal Republic of Germany

    A. Dwenger & G. Schweitzer

  2. Unfallchirurgische Klinik, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, D-3000, Hannover 61, Federal Republic of Germany

    G. Regel

Authors
  1. A. Dwenger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Regel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Schweitzer
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by the “Deutsche Forschungsgemeinschaft” project II B 6

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dwenger, A., Regel, G. & Schweitzer, G. Pathomechanisms of the adult respiratory distress syndrome (ARDS): Chemiluminescence analysis of polymorphonuclear leukocytes. Z. Anal. Chem. 324, 360–361 (1986). https://doi.org/10.1007/BF00487995

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00487995

Keywords

Search

Navigation