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Biosynthese und Struktur des Fettsäuresynthetase-Komplexes der Hefe

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Abstract

Genetic as well as biochemical data suggest that the yeast fatty-acid synthetase complex has an (AB)6 protein structure where A and B represent multifunctional polypeptide chains with molecular weights of 185000 and 180000 daltons, respectively. Subunit A contains at least 3 and subunit B4 of the 8 known biochemical functions of the multienzyme complex. It is concluded that this complex structure has evolved from the corresponding prokaryotic system of monofunctional enzymes due to a selective advantage regarding the biosynthesis and assembly of the complex components.

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Authors and Affiliations

  1. Institut für Mikrobiologie und Biochemie, Lehrstuhl für Biochemie der Universität Erlangen-Nürnberg, D-8520, Erlangen

    Eckhart Schweizer

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  1. Eckhart Schweizer
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Nach einem Vortrag anläßlich der Verleihung des Heinrich-Wieland-Preises am 5. November 1976 in München

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Schweizer, E. Biosynthese und Struktur des Fettsäuresynthetase-Komplexes der Hefe. Naturwissenschaften 64, 366–370 (1977). https://doi.org/10.1007/BF00368735

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  • DOI: https://doi.org/10.1007/BF00368735

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