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Expression of human transferrin receptor is controlled by a gene on chromosome 3: Assignment using species specificity of a monoclonal antibody

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Somatic Cell Genetics

Abstract

The monoclonal antibody OKT-9 has been shown to recognize the human transferrin receptor. We have exploited the species specificity of OKT-9 to map a gene controlling human transferrin receptor expression to chromosome 3, using human-mouse somatic cell hybrids. The gene for the human transferrin receptor and the gene controlling transferrin expression may be linked in humans.

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Authors and Affiliations

  1. Imperial Cancer Research Fund, Lincoln's Inn Fields, WC2A 3PX, London

    P. N. Goodfellow, G. Banting, R. Sutherland, M. Greaves & E. Solomon

  2. M.R.C. Biochemical Genetics Unit, Wolfson House, 4 Stephenson Way, NW1 2HE, London, UK

    S. Povey

Authors
  1. P. N. Goodfellow
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  2. G. Banting
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  3. R. Sutherland
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  4. M. Greaves
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  5. E. Solomon
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  6. S. Povey
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Goodfellow, P.N., Banting, G., Sutherland, R. et al. Expression of human transferrin receptor is controlled by a gene on chromosome 3: Assignment using species specificity of a monoclonal antibody. Somat Cell Mol Genet 8, 197–206 (1982). https://doi.org/10.1007/BF01538677

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  • DOI: https://doi.org/10.1007/BF01538677

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