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Reformation of leucyl-tRNA synthetase complexes in revertants from CHO mutant tsH1

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Somatic Cell Genetics

Abstract

A direct correlation was found to exist between increased thermolability of leucyl-tRNA synthetase and loss of the high-molecular-weight enzyme complexes in the CHO cell mutant tsH1 and its revenants. This was shown to occur apart from a differential thermostability between the complexes themselves and is supported by Michaelis constant determinations.

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Author notes

  1. Mark Klekamp

    Present address: Department of Biochemistry, University of Iowa, 52242, Iowa City, Iowa

Authors and Affiliations

  1. Department of Biological Sciences, Northern Illinois University, 60115, DeKalb, Illinois

    Mark Klekamp, Eddie Pahuski & Arnold Hampel

Authors
  1. Mark Klekamp
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  2. Eddie Pahuski
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  3. Arnold Hampel
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Klekamp, M., Pahuski, E. & Hampel, A. Reformation of leucyl-tRNA synthetase complexes in revertants from CHO mutant tsH1. Somat Cell Mol Genet 7, 725–735 (1981). https://doi.org/10.1007/BF01538760

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  • DOI: https://doi.org/10.1007/BF01538760

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