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Absorption of Etoposide (VP-16-213) from the Small Intestine of the Rat. The Potential Role of Mucus as an Absorption Rate Limiting Barrier

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Abstract

The absorption of etoposide (VP-16-213) was investigated in a perfused intestinal loop. The absorbed amount of drug was determined by collecting the blood draining the loop via cannulation of the efferent jejunal vein. The absorption rate of VP-16-213 strongly depended on the composition of the perfusion medium. The addition of taurocholate to an aqueous etoposide solution enhanced the absorption rate. When N-acetylcysteine was added to an aqueous solution, the absorption rate dropped significantly.

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Authors and Affiliations

  1. Department of Pharmaceutics, State University of Utrecht, Catharijnesingel 60, 3511 GH, Utrecht, The Netherlands

    N. Schurgers, Cornelis J. de Blaey & D. J. A. Crommelin

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  1. N. Schurgers
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  2. Cornelis J. de Blaey
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  3. D. J. A. Crommelin
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Schurgers, N., de Blaey, C.J. & Crommelin, D.J.A. Absorption of Etoposide (VP-16-213) from the Small Intestine of the Rat. The Potential Role of Mucus as an Absorption Rate Limiting Barrier. Pharm Res 2, 162–165 (1985). https://doi.org/10.1023/A:1016331904482

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