Studies on the Dissolution of Drugs from Tablets using Perturbed Angular Correlation

Abstract

The perturbed angular correlation (P.A.C.) technique was used to assess the dissolution of drugs coprecipitated with [¹¹¹In]indium chloride in tablets in vitro. The amount of drug in solution was monitored simultaneously with the amount of radioactivity in solution and these were correlated to the anisotropy values obtained by P.A.C. measurements. The results indicated that the rate of drug dissolution paralleled the change in measured anisotropy of the system. Thus, the measurement of anisotropic changes in drug-indium complexes by P.A.C. is a reliable indicator of drug dissolution and can provide meaningful dissolution data for noninvasive in vivo studies.