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Preparation of Biodegradable Microparticles Using Solution-Enhanced Dispersion by Supercritical Fluids (SEDS)

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Abstract

Purpose. We have evaluated a new process, involving solution-enhanced dispersion by supercritical fluids (SEDS), for the production of polymeric microparticles.

Methods. The biodegradable polymers, Poly (DL-lactide-co-glycolide) : copolymer composition 50:50 (DL-PLG), Poly (L-lactide) (L-PLA), Poly (DL-lactide) (DL-PLA) and Polycaprolactone (PCL), were used for preparation of microparticles using SEDS. Solutions of the polymers in organic solvents were dispersed and sprayed with supercritical CO2. Extraction of the organic solvents resulted in the formation of solid microparticles. The amounts of highly toxic solvents such as dichloromethane (MC) were reduced in the process.

Results. Microparticles were obtained from all polymers. The mean particle size and shape varied with the polymer used. The morphology of the particles was strongly affected by the choice of polymer solvent. Discrete spherical microparticles of DL-PLG were produced with a mean volumetric diameter of 130 μm. The microparticles of the L-PLA were almost spherical, and their size increased from 0.5 to 5 μm as the density of supercritical CO2 decreased. PCL formed microparticles with diameters of 30−210 μm and showed a strong tendency to form films at high pressure.

Conclusions. The SEDS process appears a promising method for production of microparticles from biodegradable polymers without the use of toxic solvents.

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Authors and Affiliations

  1. Department of Pharmaceutics, Uppsala University, BMC, P.O.B. 580, SE-751 23, Uppsala, Sweden

    Raouf Ghaderi, Per Artursson & Johan Carlfors

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  1. Raouf Ghaderi
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  2. Per Artursson
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  3. Johan Carlfors
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Correspondence to Raouf Ghaderi.

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Ghaderi, R., Artursson, P. & Carlfors, J. Preparation of Biodegradable Microparticles Using Solution-Enhanced Dispersion by Supercritical Fluids (SEDS). Pharm Res 16, 676–681 (1999). https://doi.org/10.1023/A:1018868423309

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