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Pharmacokinetics of Anthracyclines in Dogs: Evidence for Structure-Related Body Distribution and Reduction to Their Hydroxy Metabolites

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Abstract

The pharmacokinetic disposition of the anthracyclines, adriamycin (doxorubicin), daunorubicin, 4′-epi-adriamycin, carminomycin, and 4-demethoxy-daunorubicin, and the formation of their reduced C13 hydroxy metabolites were studied in dogs. The presence of a C14hydroxy group (adriamycin and 4′epi-adriamycin) drastically reduces the appearance of the C13 hydroxy metabolites in plasma. Substitution of the C4-H with C4-OH and C4-OCH3, in this rank order, decreases the area under the plasma concentration-time curves of the parent compounds and their C13 hydroxy metabolites.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, Sint Radboud Hospital, University of Nijmegen, Nijmegen, The Netherlands

    Marijn J. M. Oosterbaan

  2. Dept. of Clinical Pharmacy, Sint Radboud Hospital, University of Nijmegen, Geert Groote Plein Zuid 8, 6525, GA Nijmegen, The Netherlands

    Marijn J. M. Oosterbaan

Authors
  1. Marijn J. M. Oosterbaan
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  2. Rita J. M. Dirks
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  3. Tom B. Vree
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  4. Eppo van der Kleijn
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Oosterbaan, M.J.M., Dirks, R.J.M., Vree, T.B. et al. Pharmacokinetics of Anthracyclines in Dogs: Evidence for Structure-Related Body Distribution and Reduction to Their Hydroxy Metabolites. Pharm Res 1, 33–38 (1984). https://doi.org/10.1023/A:1016378609450

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  • DOI: https://doi.org/10.1023/A:1016378609450

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