Summary
Phosphofructokinase (PFK) isozymes and their physiological significance have been the focus of extensive research. The majority of this work has been centered around the PFK isozymes of rat, human and rabbit tissues. Consequently, this review emphasizes these studies. Additionally, a review of PFK isozymes in chickens, mice, guinea pig, and pig is presented. The relationship of the properties of each PFK isozyme in different tissues to the rates of glycolysis and/ or gluconeogenesis in those tissues is discussed where possible. Moreover, the contribution of the different PFK isozymes to alterations of the glycolytic rate in various tissues is discussed in relationship to variations in nutritional, hormonal, developmental or pathological status of the animal.
Similar content being viewed by others
References
Aaronson, R. P. and Frieden, C., 1972. J. Biol. Chem. 247: 7502–7509.
Adlard, B. P. F. and Dobbing, J., 1971. J. Neurochem. 18: 1299–1303.
Aisenberg, A. C., Reinafarje, B. and Potter, V. R., 1957. J. Biol. Chem. 224: 1099–1113.
Aisenberg, A. C., Reinafarje, B. and Potter, V. R., 1957. J. Biol. Chem. 224: 1115–1127.
Alexander, R. W., Williams, L. T. and Lefkowitz, R. J., 1975. Proc. Natl. Acad. Sci. U.S.A. 72: 1564–1568.
Atkinson, D. E. and Walton, G. M., 1965. J. Biol. Chem. 240: 757–763.
Baldwin, K. M., Cooke, D. A. and Cheadle, W. G., 1977. J. Mol. Cell. Cardiol. 9: 651–660.
Baquer, N. Z., McLean, P. and Greenbaum, A. L., 1973. Biochem. Biophys. Res. Commun. 53: 1282–1288.
Bennet, M. J., Taylor, C. B. and Timperley, W. R., 1975. Eur. J. Cancer 11: 359–363.
Bloxhan, D. P. and Lardy, H. A., 1973. In: The Enzymes (Boyer, P. D. ed.), Vol. 2, pp. 239–278, New York, Academic Press.
Brand, I. A. and Soling, H. D., 1975. FEBS Lett. 57: 163–168.
Brand, E. A. and Soling, H. D., 1974. J. Biol. Chem. 249: 7824–7831.
Burch, H. B., Lowry, O. H., Kuhlman, A. M., Skerjance, J., Diamant, E. J., Lowry, S. R. and Von Dippe, P., 1963. J. Biol. Chem. 238: 2267–2273.
Castano, J. G., Nieto, A. and Feliu, J. E., 1979. J. Biol. Chem. 254: 5576–5579.
Clark, M. G., Filsell, O. H. and Patten, G. S., 1982. J. Biol. Chem. 257: 271–276.
Clark, M. G. and Patten, G. S., 1981. J. Biol. Chem. 256: 27–30.
Clark, M. G. and Patten, G. S., 1981. Nature 292: 461–463.
Claus, T. H., Schlumpf, J. R., El-Maghrabi, M. R., Pilkis, J. and Pilkis, S. J., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 6501–6505.
Claus, T. H., Schlumpf, J., Pilkis, J., Johnson, R. A. and Pilkis, S. J., 1981. Biochem. Biophys. Res. Commun. 98: 359–366.
Cori, C. F., 1942. In: A Symposium on Respiratory Enzymes, p. 173, Madison, Wisconsin, University of Wisconsin Press.
Cottreau, D., Levin, M. J. and Kahn, A., 1979. Biochim. Biophys. Acta, 568, 183–194.
Cox, S. J. and Gunberg, D. L., 1972. J. Embryol. Exp. Morphol. 28: 235–245.
De Faria, J. B., Crivellaro, O. and Bacila, M., 1976. Comp. Biochem. Physiol. 5513: 323–329.
De Faria, J. B., El-Dorry, H. A. and Bacila, M., 1978. Devel. Biol. 65: 547–552.
DeWulf, H., Keppens, S., Vandenheede, J. R., Haustraete, F., Proost, C. and Carton, H., 1980. Hormone and Cell Regulation 4: 47–71.
Dische, Z., 1935. Biochem. Z. 280: 248–264.
Dunaway, G. A., Leung, G. L.-Y., Cooper, M. D., Thrasher, J. R. and Wagle, S. R., 1978. Biochem. Biophys. Res. Commun. 80: 71–74.
Dunaway, G. A., Leung, G. L.-Y., Thrasher, J. R. and Cooper, M. D., 1978. J. Biol. Chem. 253: 7460–7463.
Dunaway, G. A., Leung, G. L.-Y., Thrasher, J. R., Naqui, D. and Morris, H. P., 1979. Biochem. Biophys. Res. Commun. 88: 882–886.
Dunaway, G. A., Morris, H. P. and Weber, G., 1974. Cancer Res. 34: 2209–2216.
Dunaway, G. A., Naqui, D., Kruep, D., Thrasher, J. R. and Morris, H. P., 1981. Arch. Biochem. Biophys. 212: 1–8.
Dunaway, G. A. and Segal, H. L., 1974. Biochem. Biophys. Res. Commun. 56: 689–696.
Dunaway, G. A. and Segal, H. L., 1976. J. Biol. Chem. 251: 2323–2329.
Dunaway, G. A. and Weber, G., 1974. Arch. Biochem. Biophys. 162: 620–628.
Dunaway, G. A. and Weber, G., 1974. Arch. Biochem. Biophys. 162: 629–637.
El-Maghrabi, M. R., Claus, T. H., Pilkis, J. and Pilkis, S. J., 1981. Biochem. Biophys. Res. Commun. 101: 1071–1077.
El-Maghrabi, M. R., Claus, T. H., Pilkis, J. and Pilkis, S. J., 1982. Proc. Natl. Acad. Sci. U.S.A. 79: 315–319.
Engelhardt, V. A. and Sakov, N. E., 1943. Biokhimiya 8: 9–36.
Etiemble, J., Kahn, A., Boivin, P., Bernard, J. F. and Goudemand, M., 1976. Hum. Genet. 31: 83–91.
Etiemble, J., Picat, Ch., Siméon, J., Blatrix, Ch. and Boivin, P., 1980. Hum. Genet. 55: 383–390.
Exton, J. H., 1979. Biochem. Pharmacol. 28: 2237–2240.
Fazekas, J. F., Alexander, F. A. D. and Himwich, H. E., 1941. Am. J. Physiol. 134: 281–287.
Foe, L. G. and Trujillo, J. L., 1980. J. Biol. Chem. 255: 10537–10541.
Furuya, E. and Uyeda, K., 1980. J. Biol. Chem. 255: 11656–11659.
Furuya, E. and Uyeda, K., 1981. J. Biol. Chem. 256: 7109–7112.
Furuya, E. and Uyeda, K., 1980. Proc. Natl. Acad. Sci. U.S.A 77: 5861–5864.
Furuya, E., Yokoyama, M. and Uyeda, K., 1982. Biochem. Biophys. Res. Commun. 105: 264–270.
Furuya, E., Yokoyama, M., Uyeda, K., 1982. Proc. Natl. Acad. Sci. U.S.A. 79: 325–329.
Garland, P. B. and Randle, P. J., 1964. Biochem. J. 93: 678–687.
Garland, P. B., Randle, P. J. and Newsholme, E. A., 1963. Nature 200: 169–170.
Goldhammer, A. R. and Paradies, H. H., 1979. In: Current Topics in Cellular Regulation (Horecker, B. L. and Stadtman, E. R., eds.), Vol. 15, pp. 109–141, New York, Academic Press.
Gonzalez, F. and Kemp, R. G., 1978. J. Biol. Chem. 253: 1493–1497.
Gonzalez, F., Tsai, M. Y. and Kemp, R. G., 1975. Comp. Biochem. Physiol. 52B: 315–319.
Hesterberg, L. K. and Lee, J. C., 1982. Biochem. 21: 216–222.
Hickman, P. E. and Weidemann, M. J., 1975. Biochem. J. 151: 327–336.
Hoerter, J. A. and Opie, L. H., 1978. Biol. Neonat. 33: 144–161.
Hofmann, E., 1976. In: Reviews of Physiology, Biochemistry and Pharmacology, Vol. 75, pp. 1–68, Berlin and New York, Springer-Verlag.
Hommes, F. A. and Wilmink, C. W., 1968. Biol. Neonat. 12: 181–193.
Hosey, M. M., Chatterjee, T., Cohen, A. J., Stein, A. L., Kemp, R. G. and Marcus, F., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 2497–2499.
Hue, L., 1981. In: Advances in Enzymology and Related Areas of Molecular Biology (Meister, A., ed.), Vol. 52, pp. 247–331, New York, John Wiley and Sons.
Hue, L., Blackmore, P. F. and Exton, J. H., 1981. J. Biol. Chem. 256:
Hue, L., Blackmore, P. F., Shikama, H., Robinson-Steiner, A. and Exton, J. H., 1982. J. Biol. Chem. 257: 4308–4313.
Hue, L., Van Schaftingen, E. and Blackmore, P. F., 1981. Biochem. J. 194: 1023–1026.
Kagimoto, T. and Uyeda, K., 1980. Arch. Biochem. Biophys. 203: 792–799.
Kagimoto, T. and Uyeda, K., 1979. J. Biol. Chem. 254: 5584–5587.
Kahn, A., Cottreau, D., Daegelen, D. and Dreyfus, J.-C., 1981. Eur. J. Biochem. 116: 7–12.
Kahn, A. Cottreau, D. and Dreyfus, J. C., 1980. Pediatr. Res. 14: 1162–1167.
Kahn, A., Cottreau, D. and Meienhofer, M. C., 1980. Biochim. Biophys. Acta 611: 114–126.
Kahn, A., Etiemble, J., Meienhofer, M. C. and Boivin, P., 1975. Clin. Chim. Acta 61: 415–419.
Kahn, A., Meienhofer, M. C., Cottreau, D., Lagrange, J.-L. and Dreyfus, J.-C., 1979. Hum. Genet. 48: 93–108.
Karadsheh, N. S., Uyeda, K. and Oliver, R. M., 1977. J. Biol. Chem. 252: 3515–3524.
Kaur, J. and Layzer, R. B., 1977. Biochem. Genet. 15: 1133–1142.
Kemp, R. G., 1971. J. Biol. Chem. 246: 245–252.
Kirby, W., Morris, H. P. and Taylor, C. B., 1974. Eur. J. Cancer 10: 629–631.
Kirby, W. and Taylor, C.B., 1974. Int.J.Biochem. 5: 89–93.
Kirk, C. J., Rodrigues, L. M. and Hems, D. A., 1979. Biochem. J. 178: 493–496.
Kono, N., Uyeda, K. and Oliver, R. M., 1973. J. Biol. Chem. 248: 8592–8602.
Koster, J. F., Slee, R. G. and Van Berkel, T. J. C., 1980. Clin. Chim. Acta 103: 169–173.
Kurata, N., Matsushima, T. and Sugimura, T., 1972. Biochem. Biophys. Res. Commun. 48: 473–479.
Kuwajima, M. and Uyeda, K., 1982. Biochem. Biophys. Res. Common. 104: 84–88.
Lardy, H. A. and Parks, R. E., Jr., 1956. In: Enzymes: Units of Biological Structure and Function (Gaebler, O. H., ed.), pp. 584–587, New York, Academic Press.
Layzer, R. B. and Conway, M. M., 1970. Biochem. Biophys. Res. Commun. 40: 1259–1265.
Layzer, R. B. and Rasmussen, J., 1974. Arch. Neurol. 31: 411–417.
Layzer, R. B., Rowland, L. P. and Bank, W. J., 1969. J. Biol. Chem. 244: 3823–3831.
Layzer, R. B., Rowland, L. P. and Ranney, H. M., 1967. Arch. Neurol. 17, 512–523.
Leonard, K. R., and Walker, I. O., 1972. Eur. J. Biochem. 26: 442–448.
Ling, K. H., Marcus, F. and Lardy, H. A., 1965. J. Biol. Chem. 240: 1893–1899.
Maier, K. P., 1971. Biochim. Biophys. Acta 250: 75–85.
Mansour, T. E., 1972. In: Current Topics in Cellular Regulation (Horecker, B. L. and Stadtman, E. R., eds.), Vol. 5, pp. 1–46, New York, Academic Press.
Mansour, T. E., 1963. J. Biol. Chem. 238: 2285–2292.
Mansour, T. E. and Mansour, J. M., 1962. J. Biol. Chem. 237: 629–634.
Meienhofer, M. C., Carayon, P. and Gacon, G., 1972. Biochemie 54: 1399–1403.
Meienhofer, M C., Cottreau, D., Dreyfus, J. C. and Kahn, A., 1980. FEBS Lett. 110: 219–222.
Meienhofer, M. C., Lagrange, J. L., Cottreau, D., Lenoir, G., Dreyfus, J. C. and Kahn, A., 1979. Blood 54: 389–400.
Meldolesi, M. F. and Laccetti, P., 1979. J. Biol. Chem. 254: 9200–9203.
Meldolesi, M. F., Macchia, V. and Laccetti, P., 1976. J. Biol. Chem. 251: 6244–6251.
Morgan, H. E., Henderson, M. J., Regen, D. M. and Park, C. R., 1961. J. Biol. Chem. 236: 253–261.
Mörikofer-Zwez, S., Stoecklin, F. B. and Walter, P., 1981. Biochem. Biophys. Res. Commun. 101: 104–111.
Neely, J. R., Denton, R. M., England, P. J. and Randle, P. J., 1972. Biochem. J. 128: 147–159.
Neely, J. R., Liebermeister, H. and Morgan, H. E., 1967. Am. J. Physiol. 212: 815–822.
Negelein, E., 1936. Biochem. Z. 287: 329–333.
Newsholme, E. A. and Randle, P. J., 1961. Biochem. J. 80: 655–662.
Newsholme, E. A. and Randle, P. J., 1962. Biochem. J. 83: 387–392.
Newsholme, E. A. and Randle, P. J., 1964. Biochem. J. 93: 641–651.
Nieto, A. and Castano, J. G., 1980. Biochem. J. 186: 953–957.
Opie, L. H., Mansford, K. R. L. and Owen, P., 1971. Biochem. J. 124: 475–490.
Ostern, P., Guthke, I. A. and Terszakowec, J., 1936. HoppeSeyler's Z. Physiol. Chem. 243: 9–37.
Parmeggiani, A. and Bowman, R. H., 1963. Biochem. Biophys. Res. Commun. 12: 268–273.
Passonneau, J. V. and Lowry, O. H, 1962. Biochem. Biophys. Res. Commun. 7: 10–15.
Passonneau, J. V. and Lowry, O. H., 1963. Biochem. Biophys. Res. Commun. 13: 372–379.
Pavelich, M. J. and Hammes, G. G., 1973. Biochem. 12: 1408–1414.
Pilkis, S. J., El-Maghrabi, M. R., McGrane, M. M., Pilkis, J. and Claus, T., 1981. J. Biol. Chem. 256: 11489–11495.
Pilkis, S. J., El-Maghrabi, M. R., Pilkis, J. and Claus, T., 1981. J. Biol. Chem. 256: 3619–3622.
Pilkis, S. J., El-Maghrabi, M. R., Pilkis, J., Claus, T. H. and Cumming, D. A., 1981. J. Biol. Chem. 256: 3171–3174.
Pilkis, S. J., Schlumpf, J., Pilkis, J. and Claus, T. H., 1979. Biochem. Biophys. Res. Common. 88: 960–967.
Pogson, C. I. and Randle, P. J., 1966. Biochem. J. 100: 683–693.
Pokrovskii, A. A., Nikitina, L. V. and Koronvnikov, K. A., 1972. Ontogenez. 3: 512–516.
Ramachandran, C., Angelos, K. L. and Walsh, D. A.. 1982. J. Biol. Chem. 257: 1448–1457.
Ramaiah, A., 1974. In: Current Topics in Cellular Regulation (Horecker, B. L. and Stadtman. E. R., eds.), Vol. 8, pp. 297–345, New York, Academic Press.
Ramaiah, A., Hathaway, J. A. and Atkinson, D. E., 1964. J. Biol. Chem. 239: 3619–3622.
Ramaiah, A. and Tejwani, G. A., 1973. Eur. J. Biochem. 39: 183–192.
Regen, D. M., Davis, W. W., Morgan, H. E. and Parks, C. R., 1964. J. Biol. Chem. 239: 43–49.
Reinhart, G. D., 1980. J. Biol. Chem. 255: 10576–10578.
Reinhart, G. D. and Lardy, H. A., 1980. Biochem. 19: 1477–1484.
Reinhart, G. D. and Lardy, H. A., 1980. Biochem. 19: 1484–1490.
Reinhart, G. D. and Lardy, H. A., 1980. Biochem. 19: 1491–1495.
Richards, C. S., Furuya, E. and Uyeda, K., 1981. Biochem. Biophys. Res. Commun. 100: 1673–1679.
Richards, C. S. and Uyeda, K., 1980. Biochem. Biophys. Res. Common. 97: 1535–1540.
Richards, C. S., Yokoyama, M., Furuya, E. and Uyeda, K., 1982. Biochem. Biophys. Res. Commun. 104: 1073–1079.
Rognstad, R. and Katz, J., 1980. Arch. Biochem. Biophys. 203: 642–646.
Soling, H-D. and Brand, I. A., 1981. In: Current Topics in Cellular Regulation (Horecker, B. L. and Stadtman, E. R., eds.), Vol. 20, pp. 107–138, New York, Academic Press.
Spamer, C. and Pette, D., 1977. Histochemistry 52: 201–216.
Su, J. Y. and Friedman, W. F., 1973. Am. J. Physiol. 224: 1249–1253.
Sydow, G., 1969. Hoppe-Seyler's Z. Physiol. Chem. 350: 263–268.
Taketa, K., 1973. Acta Med. Okayama 27: 205–209.
Tanaka, T., An, T. and Sakaue, Y., 1971. J. Biochem. 69: 609–612.
Tarui, S., Kono, N., Nasu, T. and Nishikawa, M., 1969. Biochem. Biophys. Res. Commun. 34: 77–83.
Tarui, S., Kono, N. and Uyeda, K., 1972. J. Biol. Chem. 247: 1138–1145.
Tarui, S., Okuno, G., Ikura, Y., Tanaka, T., Suda, M. and Nishikawa, M., 1965. Biochem. Biophys. Res. Commun. 19: 517–523.
Taunton, O. D., Stifel, F. B., Greene, H. L. and Herman, R. H., 1974. J. Biol. Chem. 249: 7228–7239.
Taylor, C. B. and Bew, M., 1970. Biochem. J. 119: 797–799.
Tejwani, G. A., 1978. Trends in Biochem. Sci. 3: 30–33.
Thrasher, J. R., Cooper, M. D. and Dunaway, G. A., 1981. J. Biol. Chem. 256.
Trujillo, J. L. and Deal, W. C., Jr., 1977. Biochem. 16: 3098–3104.
Tsai, M. Y., Gonzalez, F. and Kemp, R. G., 1975. In: Isozymes II (Markert, C. L, ed.), pp. 819–835, New York, Academic Press.
Tsai, M. Y. and Kemp, R. G., 1973. J. Biol. Chem. 248: 785–792.
Tsai, M. Y. and Kemp, R. G., 1974. J. Biol. Chem. 249: 6590–6596.
Uyeda, K., 1979. In: Advances in Enzymology and Related Areas of Molecular Biology (Meister, A., ed.), Vol. 48, pp. 193–244, New York, John Wiley and Sons.
Uyeda, K., Furuya, E. and Luby, L. J., 1981. J. Biol. Chem. 256: 8394–8399.
Uyeda, K., Furuya, E. and Sherry, A. D., 1981. J. Biol. Chem. 256: 8679–8684.
Van Schaftingen, E. V. and Hers, H.-G., 1981. Biochem. Biophys. Res. Commun. 101: 1078–1084.
Van Schaftingen, E. V. and Hers, H.-G., 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 2861–2863.
Van Schaftingen, E., Hue, L. and Hers, H.-G., 1980. Biochem J. 192: 887–895.
Van Schaftingen, E., Hue, L. and Hers, H.-G., 1980. Biochem. J. 192: 897–901.
Van Schaftingen, E., Jett, M-F., Hue, L. and Hers, H.-G., 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 3483–3486.
Vora, S., 1981. Blood 57: 724–732.
Vora, S., Seaman, C., Durham, S. and Piomelli, S., 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 62–66.
Vora, S. and Francke, U., 1981. Proc. Natl. Acad. Sci. U.S.A. 78: 3738–3742.
Vora, S. and Piomelli, S., 1977. Blood 50: 87 (abstract).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dunaway, G.A. A review of animal phosphofructokinase isozymes with an emphasis on their physiological role. Mol Cell Biochem 52, 75–91 (1983). https://doi.org/10.1007/BF00230589
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00230589