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Networking with mitogen-activated protein kinases

  • Protein Phosphorylation in Signal Transduction
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Abstract

Mitogen activated protein (MAP) kinases and their target ribosomal protein S6 (RSK) kinases have been recognized as shared components in the intracellular signaling pathways of many diverse cytokines. Recent studies have extended this protein kinase cascade by identifying the major activator of vertebrate MAP kinases as a serine/threonine/tyrosine-protein kinase called MEK, which is related to yeast mating factor-regulated protein kinases encoded by the STE7 and byr1 genes. MEK, in turn, may be activated following its phosphorylation on serine by either of the kinases encoded by proto-oncogenesraf1 ormos, as well as by p78mekk, which is related to the yeast STE11 and byr2 gene products. Isoforms of all of these protein kinases may specifically combine to assemble distinct modules for intracellular signal transmission. However, the fundamental architecture of these protein kinase cascades has been highly conserved during eukaryotic evolution.

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Authors and Affiliations

  1. Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, V6T 1Z3, Vancouver, B.C., Canada

    Steven L. Pelech, David L. Charest, Guy P. Mordret, Yaw Loong Siow, Chrystal Palaty, Donna Campbell, Lorin Charlton, Mitra Samiei & Jasbinder S. Sanghera

  2. Department of Medicine, University of British Columbia, 2222 Health Sciences Mall, V6T 1Z3, Vancouver, B.C., Canada

    Steven L. Pelech, David L. Charest, Guy P. Mordret, Yaw Loong Siow, Chrystal Palaty, Donna Campbell, Lorin Charlton, Mitra Samiei & Jasbinder S. Sanghera

  3. Kinetek Biotechnology Corporation, 500-520 W. 6 Ave., Vancouver, B.C., Canada

    Steven L. Pelech, David L. Charest, Guy P. Mordret, Yaw Loong Siow, Chrystal Palaty & Donna Campbell

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  1. Steven L. Pelech
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Pelech, S.L., Charest, D.L., Mordret, G.P. et al. Networking with mitogen-activated protein kinases. Mol Cell Biochem 127, 157–169 (1993). https://doi.org/10.1007/BF01076767

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