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Nonparametric Survival Estimation when Death is Reported with Delay

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Abstract

In disease registries there can be a delay between death of asubject and the reporting of this death to the data analyst.If researchers use the Kaplan-Meier estimator and implicitlyassumed that subjects who have yet to have death reported arestill alive, i.e. are censored at the time of analysis, the Kaplan-Meierestimator is typically inconsistent. Assuming censoring is independentof failure, we provide a simple estimator that is consistentand asymptotically efficient. We also provide estimates of theasymptotic variance of our estimator and simulations that demonstratethe favorable performance of these estimators. Finally, we demonstrateour methods by analyzing AIDS survival data. This analysis underscoresthe pitfalls of not accounting for delay when estimating thesurvival distribution and suggests a significant reduction inbias by using our estimator.

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References

  • P. K. Anderson, O. Borgan, R. D. Gill and N. Keiding, Statistical Models Based on Counting Processes, Springer-Verlag: New York, 1993.

    Google Scholar 

  • P. Bacchetti, “Reporting delays of deaths with AIDS in the United States,” Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology vol. 13 pp. 363-67, 1996.

    Google Scholar 

  • P. J. Bickel, A. J. Klaassen, Y. Ritov and J. A. Wellner, Efficient and Adaptive Inference in Semi-Parametric Models, Johns Hopkins University Press: Baltimore, 1993.

    Google Scholar 

  • J. M. Colford, M. Sega, F. Tabnak, M. Chen, R. Sun and I. Tager, “Temporal trends and factors associated with survival after Pneumocystis carinii Pneumonia in California, 1983–1992,” American Journal of Epidemiology vol. 146 pp. 115-127, 1997.

    Google Scholar 

  • R. D. Gill, M. J. van der Laan and J. M. Robins, “Coarsening at Random: Characterizations, Conjectures and Counter-Examples,” in D. Y. Lin and T. R. Fleming (eds.), Proceedings of the First Seattle Symposium in Biostatistics, 1995. Springer Lecture Notes in Statistics, pp. 255-294, 1997.

  • D. F. Heitjan and D. B. Rubin, “Ignorability and coarse data,” Ann. of Statist. vol. 19 pp. 2244-53, 1991.

    Google Scholar 

  • P. H. Hu and A. A. Tsiatis, “Estimating the survival function when ascertainment of vital status is subject to delay,” Biometrika vol. 83 pp. 371-80, 1996.

    Google Scholar 

  • A. E. Hubbard, M. J. van der Laan and J. M. Robins, “Nonparametric locally efficient estimation of the treatment specific survival distribution with right-censored data and covariates in observational studies,” in E. Halloran and D. Berry (eds.), Statistical Models in Epidemiology: The Environment and Clinical Trials, Springer-Verlag: New York, pp. 135-178, 1999.

    Google Scholar 

  • M. Jacobssen and N. Keiding, “Coarsening at random in general sample spaces and random censoring in continuous time,” Ann. Statist. vol. 23 pp. 774-86, 1995.

    Google Scholar 

  • J. M. Robins and A. Rotnitzky, “Recovery of information and adjustment for dependent censoring using surrogate markers,” in N. P. Jewell, K. Dietz and V. T. Farewell (eds.), Aids Epidemiology: Methodological Issues, Birkhäuser: Boston, pp. 297-331, 1992.

    Google Scholar 

  • J. M. Robins, “Information recovery and bias adjustment in proportional hazards regression analysis of randomized trials using surrogate markers,” Pro. Biopharm. Sec., Am. Stat. Assoc. pp. 24-33, 1993.

  • X. Tu, X. Meng and M. Pagano, “The AIDS epidemic: estimating survival after AIDS diagnosis from surveillance data,” Journal of the American Statistical Association vol. 88 pp. 26-36, 1993.

    Google Scholar 

  • M. J. van der Laan and A. E. Hubbard, “Locally efficient estimation of the survival distribution with right-censored data and covariates when collection of the data is delayed,” Biometrika vol. 85 pp. 771-83, 1998.

    Google Scholar 

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Hubbard, A.E., Laan, M.J.v.d., Enanoria, W. et al. Nonparametric Survival Estimation when Death is Reported with Delay. Lifetime Data Anal 6, 237–250 (2000). https://doi.org/10.1023/A:1009689625311

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  • DOI: https://doi.org/10.1023/A:1009689625311

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