Abstract
The human tumor colony assay was used to evaluate the effect of a new chemotherapeutic agent (KW2152) on colony inhibition of four non-small cell lung cancer cell lines and a mouse cell line. With continuous exposure experiments, KW2152 induced > 70% colony inhibition of PC-7 (human adenocarcinoma), PC-10 (human squamous cell) and PC-13 (human large cell) at a drug concentration of 10 mcg/ml. In one hour exposure experiments, KW2152 caused a significant reduction in colony formation (< 30% of control) only at the highest concentration tested (100 mcg/ml). KW2152 showed significant in vitro activity against human non-small cell lung cancer cell lines. Due to these promising results, it was suggested that KW2152 should be evaluated in clinical trials.
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Jett, J.R., Saijo, N., Hong, WS. et al. The colony inhibition of a new chemotherapeutic agent (KW2152) against human lung cancer cell lines. Invest New Drugs 5, 155–159 (1987). https://doi.org/10.1007/BF00203540
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DOI: https://doi.org/10.1007/BF00203540