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Activity of Carbetimer in a human tumor cloning system

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Summary

The antitumor activity of Carbetimer was tested against 171 patient's tumors in a human tumor cloning system. Sixty-seven tumor specimens had adequate growth to be considered evaluable. In 21 specimens survival of tumor colony forming units was ≤50% that in control plates. Antitumor effect was most impressive in carcinomas of the breast, ovary, and lung. This information will be useful in planning disease oriented Phase II trials.

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Authors and Affiliations

  1. Department of Medicine, Division of Oncology, University of Texas, Health Center at San Antonio, 78284, San Antonio, TX, U.S.A.

    Daniel L. Kisner M.D. & Daniel D. Von Hoff

  2. The Monsanto Company, St. Louis, Missouri, U.S.A.

    Persis Mehta & G. Edward Paget

Authors
  1. Daniel L. Kisner M.D.
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  2. Persis Mehta
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  3. G. Edward Paget
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  4. Daniel D. Von Hoff
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Kisner, D.L., Mehta, P., Paget, G.E. et al. Activity of Carbetimer in a human tumor cloning system. Invest New Drugs 2, 55–58 (1984). https://doi.org/10.1007/BF00173787

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  • DOI: https://doi.org/10.1007/BF00173787

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