Summary
A new and extremely efficient synthesis of DDATHF from 4-vinylbenzoic acid and bromomalondialdehyde as precursors has been developed which proceeds in 48% overall yield.
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Dedicated to the memory of Dr. Gerald B. Grindey
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Taylor, E.C., Chaudhari, R. & Lee, K. A simplified and efficient synthesis of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF). Invest New Drugs 14, 281–285 (1996). https://doi.org/10.1007/BF00194531
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DOI: https://doi.org/10.1007/BF00194531