Summary
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1.
Examination of the cerebrospinal fluid (CSF) of head-injured patients reveals that the concentration of intraventricular xanthine is elevated and that of uridine is decreased relative to those of adult lumbar CSF.
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2.
No correlations were observed between CSF lactate and CSF hypoxanthine, xanthine, or uridine, suggesting that changes in purine metabolites and the pyrimidine nucleoside do not index similar cellular events as does lactic acid production.
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3.
Ventricular CSF from hydrocephalic infants had uridine and hypoxanthine concentrations not significantly different from those of normal adult lumbar CSF, but xanthine was significantly elevated.
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4.
Since uridine has anticonvulsant properties and is a crucial substrate for cerebral metabolism, it may be useful to evaluate this pyrimidine for use in the management of patients with head injury.
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References
Agnati, L. F., Fuxe, K., Eneroth, P., Zany, I., Härfstrand, A., Grimaldi, R., and Zoli, M. (1986). Intravenous uridine treatment antagonizes hypoglycemia-induced reduction in brain somatostatin-like immunoreactivity.Acta Physiol. Scand. 126525–531.
Bonovita, V., and Piccoli, P. (1971). Brain nucleotides and excitatory processes. InChemistry and Development (R. Paoletti and A. N. Davison, Eds.), Plenum Press, New York, pp. 355–373.
Castro-Gago, M., Lojo, S., Del Raw, R., Rodriguez, A., Novo, I., and Rodriguez-Segade, S. (1986). The concentrations of xanthine and hypoxanthine in cerebrospinal fluid as therapeutic guides in hydrocephalus.Child Nerv. Syst. 2109–111.
Chapman, A. G., Westerberg, E., and Siesjo, B. (1981). Metabolism of uridine and pyrimidine nucleotides in rat cortex during insulin-induced hypoglycemia and recovery.J. Neurochem. 36179–189.
Cornford, E. M., and Oldenforf, W. H. (1975). Independent blood-brain barrier transport systems for nucleic acid precursors.Biochim. Biophys. Acta 394211–219.
Eells, J. T., and Spector, R. (1983). Purine and pyrimidine base and nucleoside concentrations in human cerebrospinal fluid and plasma.Neurochem. Res. 81451–1457.
Guarneri, P., Guarneri, R., Mocciaro, C., and Piccoli, F. (1983). Interaction of uridine with GABA binding sites in cerebellar membranes of the rat.Neurochem. Res. 81537–1545.
Harkness, R. A., and Lund, R. J. (1983). Cerebrospinal fluid concentrations of hypoxanthine, xanthine, uridine and inosine: High concentrations of the ATP metabolite, hypoxanthine, after hypoxia.J. Clin. Pathol. 361–8.
Levin, S. D., Brown, J. K., and Harkness, R. A. (1984). Cerebrospinal fluid hypoxanthine and xanthine concentrations as indicators of metabolic damage due to raised intracranial pressure in hydrocephalic children.J. Neurol. Neurosurg. Psychiat. 47730–733.
MacDonnell, P., Huff, K., Grouse, L., and Guroff, G. (1980). Brain nucleic acids. InBiochemistry of Brain (S. Kumar, Ed.), Pergamon Press, New York, pp. 211–240.
Roberts, C. A. (1973). Anticonvulsant effects of uridine: Comparative analysis of metrazol and penicillin-induced foci.Brain Res. 55291–308.
Saugstad, O. D. (1975). Hypoxanthine as a measurement of hypoxia.Pediat. Res. 9158–161.
Siesjö, B. K., and Ingvar, M. (1982). Blood flow. InHandbook of Neurochemistry, Vol. 3 (A. Lajtha, Ed.), Plenum Press, New York, pp. 653–688.
Sollevi, A. (1986). Cardiovascular effects of adenosine in man: Possible clinical implications.Prog. Neurobiol. 27319–340.
Weisner, B., and Bernhart, W. (1978). Protein fractions of lumbar cisternal and ventricular cerebrospinal fluid.J. Neurol. Sci. 37205–214.
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Mueller, R.A., Rosner, M.J., Ghia, J.N. et al. Alterations in cerebrospinal fluid uridine, hypoxanthine, and xanthine in head-injured patients. Cell Mol Neurobiol 8, 235–243 (1988). https://doi.org/10.1007/BF00711249
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DOI: https://doi.org/10.1007/BF00711249