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Molecular neurobiology and pharmacology of the Vasopressin/Oxytocin receptor family

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Summary

1. VP and OT mediate their wealth of effects via 4 receptor subtypes V1a, V1b, V2, and OT receptors.

2. We here review recent insights in the pharmacological properties, structure activity relationships, species differences in ligand specificity, expression patterns, and signal transduction of VP/OT receptor.

3. Furthermore, the existence of additional VP/OT receptor subtypes is discussed.

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Authors and Affiliations

  1. Rudolf Magnus Institute for Neurosciences, Department of Medical Pharmacology, Utrecht University, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands

    J. Peter, H. Burbach & Roger A. H. Adan

  2. Laboratory of Cell Biology National Institute of Mental Health, 20892, Bethesda, MD

    Stephen J. Lolait & Miklos Palkovits

  3. Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands

    Fred W. van Leeuwen

  4. Clinical Neuroscience Branch, National Institute of Neurological Diseases and Stroke, 20892, Bethesda, MD

    Eva Mezey

  5. Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Rue de la Cardonille, 34094, Montpellier Cedoc 5, France

    Claude Barberis

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  1. J. Peter
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  2. H. Burbach
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  3. Roger A. H. Adan
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  6. Eva Mezey
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  8. Claude Barberis
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Peter, J., Burbach, H., Adan, R.A.H. et al. Molecular neurobiology and pharmacology of the Vasopressin/Oxytocin receptor family. Cell Mol Neurobiol 15, 573–595 (1995). https://doi.org/10.1007/BF02071318

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  • DOI: https://doi.org/10.1007/BF02071318

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