Abstract
A single peptide difference has been found in tryptic digests of human transferrins C and DChi. The peptide isolated from Tf C was shown to have the sequence Asp-Ser-Ala-His-Gly-Phe-Leu-Lys. The corresponding peptide from Tf DChi has the composition (Gly, Phe, Leu, Lys). Apparently, histidine of the Tf C peptide has been replaced by lysine or arginine in Tf DChi, producing a new point of attack for trypsin. On the basis of the genetic code, arginine is proposed as the replacement.
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Additional information
Supported by U.S. Public Health Service grants # GM 09326, # 5-K3-GM-18,381, and # GM 00337 from the National Institutes of Health. From the Department of Zoology, The University of Texas, Austin.