Abstract
A decrease in glutathione peroxidase and glutathione reductase activity in sarcoma C-45 was discovered during the period of its most rapid growth. Repeated injections of sarcolysin (1.2 mg/kg, intraperitoneally) caused a sharp decrease in the activity of both enzymes and a simultaneous decrease in the ratio between glutathione reductase and glutathione peroxidase activities. It is suggested that the glutathione redox enzyme system plays an important role in the mechanisms of the antitumor action of chemotherapeutic agents.
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Babushkin, V.A., Arkhangel'skaya, A.V. & Gerasimov, A.M. Effect of sarcolysin on glutathione peroxidase and glutathione reductase activity in sarcoma C-45. Bull Exp Biol Med 84, 1622–1625 (1977). https://doi.org/10.1007/BF00801698
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DOI: https://doi.org/10.1007/BF00801698