Abstract
Repeated administration of xanthurenic acid to experimental animals completely eliminates insulin stores in pancreatic B cells and attenuates normalization of blood glucose level in the glucose tolerance test. Xanthurenic acid inhibits insulin secretion by isolated pancreatic islets and decreases zinc-specific luminescent reaction in B cells.
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References
E. Albert,Selective Toxicity [in Russian], (1971).
E. A. Bozhevol'nov and G. V. Serebryakova, in:Chemical Reagents and Preparations [in Russian], Moscow (1961), Issue 21, pp. 36–41.
Ya. A. Lazaris, V. M. Krasavin, V. M. Dziomko, and Z. E. Bavel'skii,Pat. Fiziol., No. 5, 39–43 (1971).
Ya. A. Lazaris and G. G. Meiramov,Probl. Endokrinol., No. 5, 90–94 (1974).
G. G. Meiramov and N. I. Trukhanov,, No. 6, 92–95 (1975).
G. G. Meiramov, G. T. Tusupbekova, and R. G. Meiramova,, No. 6, 49–51 (1987).
R. E. Coalson,Stain Technol.,41, No. 2, 121–129 (1966).
G. Gomori,Am. J. Pathol.,20, 665–666, (1950).
Y. Kotake and T. Inada,J. Biochem. (Tokyo),40, No. 3, 287–289 (1953).
Y. Kotake and M. Kalo,Proc. Jpn. Acad.,32, No. 5, 361–365 (1956).
Y. Kotake and T. Mori,, No. 4, 247–251 (1955).
G. G. Meyramov, I. G. Akmayev, A. P. Andreewa,et al., Can. J. Physiol. Pharmacol.,72, No. 1, 602 (1994).
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 6, pp. 669–672, June, 1997
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Meiramov, G.G., Andreeva, A.P. & Kohnert, K.D. Investigation of diabetogenic action of xanthurenic acid. Bull Exp Biol Med 123, 582–584 (1997). https://doi.org/10.1007/BF02458084
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DOI: https://doi.org/10.1007/BF02458084